Results 31 to 40 of about 99,233 (263)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
Macroeconomic Trend Dominance: A Multiresolution (MODWT) Analysis of the BET Index [PDF]
Revista de Studii FinanciareThis paper applies multiresolution analysis based on the Maximal Overlap Discrete Wavelet Transform (MODWT) to investigate the structural dynamics of the BET index from the perspective of systemic risk and capital market dynamics in Romania.
Marius Cristian Acatrinei +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Studia Universitatis Moldaviae: Stiinte reale si ale naturii, 2015 ANALYSIS OF VARIANCE OF QUANTITATIVE TRAITS IN AGRONOMIC FIELD EXPERIMENTS AND ITS CONECTION WITH THE LAW OF NORMAL DISTRIBUTION A new, mathematically easier for biologists, the analysis of variance procedure as an alternative approach in the study ...
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Feedforward and Feedback Control Performance Assessment for Nonlinear Systems
Abstract and Applied Analysis, 2014 A performance assessment method for nonlinear feedforward and feedback control systems is proposed in this paper. First, the existence of minimum variance performance bound for two nonlinear systems with different structures is analyzed, and the closed ...
Zhiguo Wang, Jun Chen
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Environmental and Climate Technologies, 2017 The purview of paper pivoted around the pyrolysis decomposition of forest waste (pine needle litter) by thermogravimetric analysis (TGA). Experiments were carried out in the presence of Nitrogen atmosphere.
Dhaundiyal Alok, Tewari Pramod
doaj +1 more source