Results 61 to 70 of about 340,891 (266)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Challenging choice: a media study of anti-abortion movements in India

open access: yesSexual and Reproductive Health Matters
In recent years, the backlash against abortion and reproductive autonomy has grown, driven by authoritarian regimes and conservative ideologies. In 2023, CommonHealth conducted a study to identify key anti-choice entities in India, examine their global ...
Ragini Bordoloi   +3 more
doaj   +1 more source

Argument Alternation in Persian: The Role of “Ra” and Holistic Reading in Locative Alternation [PDF]

open access: yesمطالعات زبان‌‌ها و گویش‌های غرب ایران, 2018
The appearance of arguments of a verb in different ways is called Argument Alternation. The aim of this paper is to study locative alternation in Persian.
Ali Safari
doaj  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Тема индии в творчестве Семена Чуйкова

open access: yesИскусство Евразии, 2019
Статья посвящена творчеству советского живописца, народного художника, академика АХ СССР Семена Афанасьевича Чуйкова. В фокусе внимания автора живописные произведения художника, посвященные Индии.
Филиппова, Ольга Николаевна
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

The motifs of death and resurrection in Neil Gaiman’s works

open access: yesACROSS
Renowned for his reliance on the rich literary tradition in the form of references to poetry, prose, and popular culture, Neil Gaiman reimagines and reinterprets sources from myth and traditional folklore and modern, contemporary folklore to meet his ...
Irina RAȚĂ
doaj   +3 more sources

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