Results 201 to 210 of about 2,665,540 (305)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Pastoral Care Provision for Medical Students: What Is the Role of the Clinical Teaching Fellow? [PDF]

Clin Teach
McSwiney NT, Taylor N, Jennings S.
europepmc   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source

Pricing models for diagnostic AI based on qualitative insights from healthcare decision makers. [PDF]

NPJ Digit Med
Kirchhoff J, Berns F, Schieder C, Schobel J.   +3 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Preferences of ICU Nurses for Improving Their Work System: A Sequential Exploratory Mixed-Methods Study. [PDF]

Nurs Crit Care
Mohammadinejad A, Piranveyseh P, Cousins R, Mokarami H.   +3 more
europepmc   +1 more source

Theme & Calls

, 2019
openaire   +1 more source

Drama and Catholic Themes [PDF]

, 2012
Block, Edwin
core   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Needs and health-related quality of life domains relevant to people in Europe with advanced cancer in need of palliative care: a systematic review of qualitative research. [PDF]

Qual Life Res
Lizano-Barrantes C, Amat-Fernandez C, Garin O, Luer-Aguila R, Pardo Y, Rojas-Concha L, Thong MSY, Apolone G, Brunelli C, Caraceni A, Couespel N, Bos N, Groenvold M, Kaasa S, Ciliberto G, Lombardo C, Pietrobon R, Pravettoni G, Sirven A, Vachon H, Gilbert A, Velikova G, Ferrer M, EUonQoL Working Group.   +23 more
europepmc   +1 more source