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Theophylline Dosage

Pediatrics, 1982
The article by Shapiro et al1 wherein a nomogram relating daily theophylline dose requirements to single serum levels appears to us either misleading or in error. According to our calculations, the upper and lower limits depending on K = 0.07 to 0.5 hr-1 would give a value with no units: dose (mg/kg/day) = K x V x 24 hr x 10 µg/ml = 0.07 liter/hr x 0 ...
A S, Kirshenbaum, O L, Frick
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Theophylline fatalities

Forensic Science International, 1980
Two fatal cases are presented involving the acute ingestion of theophylline resulting in blood theophylline concentrations greater than one hundred times the accepted therapeutic range.
C L, Winek   +3 more
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Theophylline poisoning

The Journal of Pediatrics, 1977
Three cases of theophylline poisoning in young children, two of which occurred after erroneous administration of commonly prescribed pediatric drugs, are presented. The possible association of hyperglycemia and ketoacidosis with severe theophylline toxicity is discussed.
Y, Vaucher, E S, Lightner, P D, Walson
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Theophylline Reassessed

Annals of Internal Medicine, 1984
Advances have recently been made in understanding the pharmacokinetics of theophylline. To correlate the new knowledge of theophylline pharmacokinetics with the drug's current status in therapy, we have critically reviewed the relevant investigations of the last 5 years.
M, Bukowskyj, K, Nakatsu, P W, Munt
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