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Theophylline toxicity

Journal of Allergy and Clinical Immunology, 1985
The adverse effects of theophylline were recognized soon after its introduction into clinical medicine. Reports of major toxic reactions to theophylline, particularly in children, discouraged its use and led to homeopathic dosing recommendations that had little therapeutic effect.
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Theophylline in Asthma

New England Journal of Medicine, 1996
Theophylline has been a popular medication for asthma for over 50 years. However, the introduction of newer pharmacologic agents, concern about the toxicity of theophylline, and recommendations in widely disseminated guidelines have recently contributed to its decreased use.
M, Weinberger, L, Hendeles
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Theophylline poisoning

The Journal of Pediatrics, 1977
Three cases of theophylline poisoning in young children, two of which occurred after erroneous administration of commonly prescribed pediatric drugs, are presented. The possible association of hyperglycemia and ketoacidosis with severe theophylline toxicity is discussed.
Y, Vaucher, E S, Lightner, P D, Walson
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Theophylline Revisited

Allergy and Asthma Proceedings, 1996
For over 50 years, theophylline has been used regularly for the management of chronic asthma. However, because of its perceived narrow therapeutic index and the fact that it has been considered a weak bronchodilator, the use of theophylline therapy has diminished.
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Theophylline toxicity

The Journal of Emergency Medicine, 1993
Theophylline toxicity continues to be a commonly encountered clinical problem. Patients may present with a vast array of toxic manifestations, including life-threatening cardiovascular and neurologic toxicity. Despite the considerable attention this topic has received in the literature, there remain some important controversies regarding the ...
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Dialysability of Theophylline

Journal of Dialysis, 1978
We have shown that theophylline is highly dialysable with an average dialysis clearance of 76 ml/min approaching 63% of urea clearance with hemodialysis. Implications include dose adjustment during dialysis and efficacy of dialytic technique in the treatment of theophylline intoxication.
N D, Vaziri   +3 more
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Theophylline in asthma

Pediatrics, 1976
In this issue of Pediatrics, Ellis et al.1 have a study of the pharmocokinetics of theophylline, a study which is 40 years overdue and which was technically feasible 25 years ago. They show that children are not "little adults" in that the dosage of theophylline and the dosing intervals in children cannot be based on adult studies.
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Theophylline Poisoning

Pediatrics, 1984
To the Editor.— The conclusions in the recent letter by Kossoy et al1 and the reply by Sahney2 regarding the original report3 suggesting conservative treatment of high theophylline levels until neurologic signs are present do not adequately consider the high frequency of mortality and serious neurologic sequelae once theophylline-induced
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Theophylline Toxicity due to Impaired Theophylline Degradation

American Review of Respiratory Disease, 1974
Abstract A 72-year-old man with severe chronic obstructive pulmonary disease and normal liver function had convulsions at a time when his serum theophylline level was 86 µg per ml. The day before convulsing he had received 960 mg of theophylline (17.5 mg per kg).
M H, Jacobs, R M, Senior
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The Theophylline-Erythromycin Interaction

Chest, 1983
Since its publication in 1976, the original report of an interaction between erythromycin and theophylline by Cummin, Kozak, and Gillman has generated considerable interest and controversy. Many studies with considerably different designs have been performed to address this question. Those studies that most closely simulate the clinical setting suggest
Jonkman, JHG, Hendeles, L
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