Results 51 to 60 of about 2,279,863 (316)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Theoretical analysis of dynamic processes for interacting molecular motors

, 2015
Biological transport is supported by the collective dynamics of enzymatic molecules that are called motor proteins or molecular motors. Experiments suggest that motor proteins interact locally via short-range potentials.
Teimouri, Hamid, Kolomeisky, Anatoly B., Mehrabiani, Kareem   +2 more
core   +1 more source

Transductions in Arithmetic [PDF]

, 2015
In this paper we study a new relation between sentences: transducibility. The idea of transducibility is based on an analysis of Feferman's Theorem that the inconsistency of a theory U is interpretable over U.
Visser, A., OFR - Theoretical Philosophy
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Leveraging public AI tools to explore systems biology resources in mathematical modeling

npj Systems Biology and Applications
Predictive mathematical modeling is an essential part of systems biology and is interconnected with information management. Systems biology information is often stored in specialized formats to facilitate data storage and analysis.
Meera Kannan, Gabrielle Bridgewater, Ming Zhang, Michael L. Blinov   +3 more
doaj   +1 more source

Mechanical Analysis of Deformation Law in the Flange Area of Box-Shaped Parts during Deep Drawing

Machines, 2022
The investigation of deformation law is the theoretical basis for analyzing instability wrinkling and forming performance during the sheet-metal-forming process.
Duan Chen, Changcai Zhao, Xiaoyi Chen, Guang Chen   +3 more
doaj   +1 more source

A theoretical analysis of the HIFF problem [PDF]

Proceedings of the 7th annual conference on Genetic and evolutionary computation, 2005
We present a theoretical analysis of Watson's Hierarchical-if-and-only-if (HIFF) problem using a variety of tools. These include schema theory and course graining, the concept of effective fitness, and statistical analysis. We first review the use of Stephen's exact schema equations and schema basis to compute the changes in population distributions ...
Nicholas Freitag McPhee, Ellery Fussell Crane   +1 more
openaire   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Theoretical Modeling and Optimization of the Detection Performance: a New Concept for Electrochemical Detection of Proteins in Microfluidic Channels

, 2006
In this work, we present a complete theoretical analysis of a new concept of electrochemical detector for application in proteomics upon considering two band microelectrodes performing in generator-collector mode.
Thouin, L., Oleinick, A., da Mota, N., Svir, I., Amatore, C.   +4 more
core   +1 more source

Maximum Delay Analysis of Fixed Backoff in IEEE 802.11 Considering Significant Interference for In-Vehicle Wireless Communication

IEEE Access
In in-vehicle wireless communication, each in-vehicle sensor terminal transmits small data in a cycle within which all terminals must transmit data successfully. Clarifying the delay characteristics in such networks is useful for the system design.
Kosuke Sanada, Takumi Shiohara, Atsuhiro Iwaki, Takeshi Hirai, Tutomu Murase   +4 more
doaj   +1 more source