Results 61 to 70 of about 1,819,221 (292)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2014 The intramolecular C–H insertion of the Mes*-substituted phosphanylidenecarbene [Mes*P=C:] (Mes* = 2,4,6-t-Bu3C6H2) and physicochemical properties of the cyclized product, 6,8-di-tert-butyl-3,4-dihydro-4,4-dimethyl-1-phosphanaphthalene were studied based
Masaaki Yoshifuji, Shigekazu Ito
doaj +1 more source
Yantu gongcheng xuebao, 2023 The proposed method focuses on the deformation characteristics of joints of immersed tube tunnels under cyclic load coupling. By establishing the tunnel-soil interaction model, the tunnel is simplified to the Timoshenko beam model, and the foundation is ...
ZHOU Huanzhu 1, 2, YU Ying 1, HOU Jinfang 3, YU Jin 4, WANG Yanning 1, 5
doaj +1 more source
THEORETICAL CALCULATIONS OF AN OSMIUM MOLECULAR SWITCH [PDF]
Journal of the Chilean Chemical Society, 2013 ABSTRACT We have investigated the molecular, electronic and optical properties of the [Os(tpy-py) 2 ] 2+ complex (tpy-py = 4’-(4-pyridyl)-2,2’:6’,2’’-terpyridine) and its protonated derivative [Os(tpy-pyH) 2 ] 4+ through Density Functional Relativistic calculations including Scalar and Spin Orbit corrections.
MIRANDA-BARRIENTOS, FERNANDO +3 more
openaire +9 more sources
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
SensorsA reliable and efficient rail track defect detection system is essential for maintaining rail track integrity and avoiding safety hazards and financial losses. Eddy current (EC) testing is a non-destructive technique that can be employed for this purpose.
Yuchun Shao +8 more
doaj +1 more source
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
Hyperfine structure of S states in Li and Be^+
, 2008 A large-scale configuration-interaction (CI) calculation is reported for the hyperfine splitting of the 2^2S and 3^2S states of ^7Li and ^9Be^+. The CI calculation based on the Dirac-Coulomb-Breit Hamiltonian is supplemented with a separate treatment of ...
J. R. Sapirstein, V. A. Yerokhin
core +1 more source
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source