Results 61 to 70 of about 1,794,096 (279)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Artificial Intelligence (ChatGPT) and Bloom’s Taxonomy in Theoretical Computer Science Education

Applied Sciences
The study focuses on evaluating the performance of AI-based tools, specifically ChatGPT versions 3.5 and 4.0, in comparison to human students in the field of Theoretical Computer Science Education.
Hashim Habiballa, Martin Kotyrba, Eva Volna, Vladimir Bradac, Martin Dusek   +4 more
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Quantum Applications In Political Science [PDF]

, 2020
Undergraduate Research ScholarshipThis paper will show the current state of quantum computation and its application as a political science research method.
Costa, Caleb
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Exploiting the structure effectively and efficiently in low rank matrix recovery

, 2018
Low rank model arises from a wide range of applications, including machine learning, signal processing, computer algebra, computer vision, and imaging science.
Absil, Agarwal, Ahmed, Alter, Amelunxen, Beck, Blanchard, Blumensath, Boumal, Boyd, Bunk, Cai, Cai, Cai, Cai, Cai, Cai, Candes, Candes, Candes, Candes, Candes, Candès, Candès, Candès, Candès, Carmon, Chandrasekaran, Chen, Chen, Chen, Chen, Chen, Chen, Chen, Chen, Chen, Combettes, Davenport, Davenport, Ding, Donoho, Fazel, Ge, Ge, Ge, Goldberg, Gross, Hardt, Harrison, Huang, Jaggi, Jain, Jain, Ji, Jin, Keshavan, Kim, Kliesch, Koltchinskii, Krim, Kueng, Lanman, Li, Li, Lin, Ling, Ling, Liu, Liu, Lustig, Ma, Miao, Mishra, Mishra, Mishra, Mobahi, Mu, Negahban, Netrapalli, Ngo, Potter, Qu, Recht, Recht, Schermelleh, Srebro, Strohmer, Sun, Sun, Tanner, Tanner, Tao, Tharrault, Toh, Toh, Tomasi, Tu, Vandereycken, Wang, Wei, Wei, Wei, Wen, WenHuang, Xu, Yi, Zhang, Zhang, Zheng   +109 more
core   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source

ORGANIZATION OF PEDAGOGICAL CONDITIONS COMPUTER AND INFORMATION TRAINING IN SYSTEM OF ADDITIONAL PROFESSIONAL EDICATION

Sovremennye Issledovaniâ Socialʹnyh Problem, 2016
The article presents the results of theoretical analysis of pedagogical researches of creating conditions of computer-learning using the information and the teaching materials on the basis of academic disciplines: social sciences and humanities and ...
Alexey Anatol’evich Oleynikov, Almira Aykaydarovna Mukasheva   +1 more
doaj   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source