Results 61 to 70 of about 656,567 (302)
The Era of Big Data Comes to Oceanography [PDF]
Oceanography, 2013 The late Jim Gray, who received the prestigious Turing Award in computer science and was a pioneer in the development of relational databases, proposed the "Fourth Paradigm" to describe the field of data-intensive science (Hey et al., 2009).
Mark R. Abbott
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Фізико-математична освіта, 2021 Relevance and expediency of introduction of a training course of computer mathematics for students of “Secondary Education (Computer Science)” is caused by necessity of use of computer equipment with the corresponding software almost in all areas of ...
Варвара Черненко
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The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
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Input Redundancy for Parameterized Quantum Circuits
Frontiers in Physics, 2020 One proposal to utilize near-term quantum computers for machine learning are Parameterized Quantum Circuits (PQCs). There, input is encoded in a quantum state, parameter-dependent unitary evolution is applied, and ultimately an observable is measured. In
Francisco Javier Gil Vidal +2 more
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Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
Lagrange Dual Method for Sparsity Constrained Optimization
IEEE Access, 2018 In this paper, we investigate the l0 quasi-norm constrained optimization problem in the Lagrange dual framework and show that the strong duality property holds.
Wenxing Zhu +3 more
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A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
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IEEE Open Journal of Intelligent Transportation Systems, 2022 Real-time load information in public transport is of high importance for both passengers and service providers. Neural algorithms have shown a high performance on various object counting tasks and play a continually growing methodological role in ...
Robert Seidel +4 more
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FEBS Letters, EarlyView.Most MmpLs transport lipids and glycolipids of the complex mycomembrane of mycobacteria. This study shows that MmpL10 from Mycobacterium smegmatis, the transporter of the trehalose polyphosphate precursor, harbors a coiled‐coil‐like extension. Biochemical and electron microscopy studies demonstrate that the coiled‐coil enables MmpL10 to trimerize.
Julie Couston +7 more
wiley +1 more source
Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells
Molecular Oncology, EarlyView.In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi +3 more
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