Results 81 to 90 of about 2,032,139 (266)
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
THE LEVEL OF THEORETICAL COMPONENT OF GEOLOGY [PDF]
Минералогия, 2015 The terms «theory» and «theoretical science» are examined. The state of geology as a scientific discipline is evaluated. The major directions are shown and the basic principles of increase in the level of geology as theoretical science are outlined.
M.P. Pokrovsky
doaj
Historical Sociolinguistic Philology – a New Hybrid Discipline, its Interests, and its Scope
Open Linguistics, 2017 This contribution presents the basic rationale and principles of a new hybrid discipline of historical sociolinguistic philology, or the sociolinguistically informed study of ancient texts, as showcased in the current special issue.
Soukup Barbara
doaj +1 more source
, 2020 This chapter assesses three areas of theoretical work: metatheory, via Jason Demers’ The American Politics of French Theory: Derrida, Deleuze, Guattari, and Foucault in Translation and Galin Tihanov’s The Birth and Death of Literary Theory: Regimes of Relevance in Russia and Beyond; three studies that theorize on the history of theory, John E ...
openaire
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Theories or No Theories—Is Anything Evolving?
Cambridge Quarterly of Healthcare Ethics, 2023 Takala, Tuija, Häyry, Matti
openaire +3 more sources