Results 101 to 110 of about 7,470,132 (265)

F-Theory, spinning black holes and multi-string branches [PDF]

open access: yes, 2016
We study 5d supersymmetric black holes which descend from strings of generic $\mathcal{N}=(1,0)$ supergravity in 6d. These strings have an F-theory realization in 6d as D3 branes wrapping smooth genus $g$ curves in the base of elliptic 3-folds.
Vafa, Cumrun   +10 more
core   +2 more sources

The ontology of the dot

open access: yesChakiñan, 2017
Along with the technics that allows archaeology to adopt a precise knowledge about the composition of the materiality, also exists a critical thought that claims for take into account experience, perception and creativity.
José Antonio Mármol Martínez
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

$N=2^∗$ (non-)Abelian theory in the $\Omega$ background from string theory [PDF]

open access: yes, 2017
We present a D-brane realisation of the Abelian and non-Abelian N = 2 ∗ theory both in five and four dimensions. We compute topological amplitudes in string theory for Ω deformed spacetime first with one and then with two parameters.
Samsonyan, Marine   +5 more
core   +2 more sources

Who is a theorist?

open access: yesRevista Eureka sobre Enseñanza y Divulgación de las Ciencias, 2011
This article carefully analyzes a recent paper by Weisberg in which it is claimed that when Mendeleev discovered the periodic table he was not working as a modeler but instead as a theorist.
Eric Scerri
doaj  

Meta-analysis for Supporting Empirical Theories in Educational Sciences

open access: yesNauki o Wychowaniu
This article explores the role of meta-analysis and systematic review in developing and refining empirical theories in educational sciences. It highlights the method’s value in synthesizing research findings, identifying patterns, and improving the ...
Sławomir Pasikowski
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

open access: yesFEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

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