Results 121 to 130 of about 14,381,304 (348)

MAMI Manual v1.0: A Source Manual for the Diagnostic Practical Theory of Structural Exposure

open access: yes
MAMI Manual v1.0 presents the source manual for the diagnostic practical theory of Structural Exposure within MAMI Theory, defined as Meta-Architecture of Mind and Invisibility.
Theory, Mami
core   +2 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Music Theory & Analysis : International journal of the Dutch-Flemish Society for Music Theory.

open access: yes
Samengevoegd met: Music Theory & Analysis Online [ISSN 2295-5925]Voortzetting van: Dutch Journal of Music Theory [ISSN 1385 ...
Dutch-Flemish Society for Music Theory
core  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Thematic, research design and theory application of business internship research: a systematic review

open access: yesCogent Education
This study provides a comprehensive review of the research design, themes, and theoretical development of internship literature in the context of business students.
Edem Maxwell Azila-Gbettor   +3 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

open access: yesFEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux   +7 more
wiley   +1 more source

Theories or No Theories—Is Anything Evolving?

open access: yesCambridge Quarterly of Healthcare Ethics, 2023
Takala, Tuija, Häyry, Matti
openaire   +3 more sources

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

open access: yesFEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos   +9 more
wiley   +1 more source

Not Everyone Will Be Taken into the Future? The Role of Forecasting in International Relations Theory

open access: yesМеждународная аналитика
The 2010s witnessed intensified debates in international academia on the relationship between theory and forecast, but Russian scholarship remained detached from these discussions. This article intends to examine the contribution of theory to forecasting
I. А. Istomin
doaj   +1 more source

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