Results 111 to 120 of about 14,295,763 (304)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
International Journal of Modern Physics D, 2009 In quantum gravity, one seeks to combine quantum mechanics and general relativity. In attempting to do so, one comes across the "problem of time" impasse: the notion of time is conceptually different in each of these theories. In this paper, I consider the timeless records approach to resolving this.
openaire +3 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
ReS Futurae, 2013 Dans cet entretien, Ugo Bellagamba et Éric Picholle présentent les enjeux théoriques des Journées Science et Fiction de Peyresq, consacrées chaque année à des réflexions sur les rapports entre la science-fiction et les différents champs du savoir.
Ugo Bellagamba +3 more
doaj +1 more source
, 2008 ‘Games & Theory’ was an international exhibition of the work of contemporary artists who share interests in play, sports and gaming. It was curated by Hammonds for the South London Art Gallery (SLG) in summer 2008. Conventionally, play is understood as
Hammonds, Kit
core
Theory and Practice of Logic Programming, 2007 AbstractWe present in this paper a general algorithm for solving first-order formulas in particular theories called decomposable theories. First of all, using special quantifiers, we give a formal characterization of decomposable theories and show some of their properties.
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The Year's Work in Critical and Cultural Theory, 2022 Taking its cue from Jonathan Kramnick’s Criticism and Truth, ‘Theory on Theory’ this year examines some of the core practices that mark literary criticism and theory. In Section 1, Kramnick’s work, which focuses on criticism as a distinct writing practice, is reviewed, along with a brief consideration of teaching in the form of Fredric Jameson’s ...
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source