Results 111 to 120 of about 14,381,304 (348)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Temporal Entanglements, Fragmented Spaces: Planning, Politics, and Place Rhythms
Urban PlanningWhat does it mean for urban planners and designers to shape places through and with time? The 2020 public health restrictions highlighted the relevance of Carlos Moreno’s et al.
Aysegul Can +2 more
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
, 2020 This chapter assesses three areas of theoretical work: metatheory, via Jason Demers’ The American Politics of French Theory: Derrida, Deleuze, Guattari, and Foucault in Translation and Galin Tihanov’s The Birth and Death of Literary Theory: Regimes of Relevance in Russia and Beyond; three studies that theorize on the history of theory, John E ...
openaire
Dipole Deformations of N=1 SYM and Supergravity backgrounds with U(1) X U(1) global symmetry [PDF]
, 2005 We study SL(3,R) deformations of a type IIB background based on D5 branes that is conjectured to be dual to N=1 SYM. We argue that this deformation of the geometry correspond to turning on a dipole deformation in the field theory on the D5 branes.
Gursoy, Umut +3 more
core
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Differential equivariant K-theory [PDF]
, 2009 textFollowing Hopkins and Singer, we give a definition for the differential equivariant K-theory of a smooth manifold acted upon by a finite group. The ring structure for differential equivariant K-theory is developed explicitly.
Ortiz, Michael Luis, 1979- +1 more
core
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source