Results 111 to 120 of about 7,470,132 (265)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
THE LEVEL OF THEORETICAL COMPONENT OF GEOLOGY [PDF]
Минералогия, 2015 The terms «theory» and «theoretical science» are examined. The state of geology as a scientific discipline is evaluated. The major directions are shown and the basic principles of increase in the level of geology as theoretical science are outlined.
M.P. Pokrovsky
doaj
Historical Sociolinguistic Philology – a New Hybrid Discipline, its Interests, and its Scope
Open Linguistics, 2017 This contribution presents the basic rationale and principles of a new hybrid discipline of historical sociolinguistic philology, or the sociolinguistically informed study of ancient texts, as showcased in the current special issue.
Soukup Barbara
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
, 2014 Simple Color Theory Infographic. Made it to the Adobe Design Achievement Awards Semi-Finals for Infographics in 2010.
Color Theory Infographic
core
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
, 2020 The advent of Malinowski’s ethnographic theory is inscribed in a wider modernist environment, which set the ground for the emergence of new epistemological projects.
Tateo, Giuseppe
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Regeneration in random combinatorial structures [PDF]
, 2010 Kingman’s theory of partition structures relates, via a natural sampling procedure, finite partitions to hypothetical infinite populations. Explicit formulas for distributions of such partitions are rare, the most no- table exception being the Ewens ...
Sub Stochastics and Decision Theory begr +2 more
core +1 more source