Results 131 to 140 of about 3,415,837 (298)
FEBS Open Bio, EarlyView.A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti +3 more
wiley +1 more source
Adversarial alignment enables competing models to engage in cooperative theory building toward cumulative science. [PDF]
Proc Natl Acad Sci U S A, 2020 Ellemers N +4 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
Building Quality, Building Green: Conventions Theory and Industry Transformation [PDF]
Urbani Izziv, 2012 Conventions theory was developed in part to explain how heterogeneous actors with asymmetrical information manage to carry out economic transactions.
Julie Cidell
doaj
Building blocks for theories of consciousness
Consciousness and CognitionConsciousness science is brimming with theories attempting to explain what consciousness is and how it can be identified in natural and artificial systems. These theories often make different and conflicting claims, evincing that the road to a mature theory of consciousness is still long and convoluted.
Lopez, Azenet L., Wiese, Wanja
openaire +3 more sources
FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Axion theory and model building
Proceedings of 1st General Meeting and 1st Training School of the COST Action COSMIC WSIPers — PoS(COSMICWISPers)Axions are light pseudoscalar bosons postulated with many motivations in particle physics and cosmology, including the strong CP problem and the dark matter in our Universe. In this lecture notes, we discuss a variety of known ultraviolet (UV) theories for axions and their low energy properties.
Choi, Kiwoon, Righi, Nicole
openaire +2 more sources
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source