Results 71 to 80 of about 280,132 (263)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Preliminary Study on the Bending Behavior of Solid Timber Beams Reinforced with Basalt Fiber-Reinforced Polymer Bars

Applied Sciences
The purpose of this work is to test the effectiveness of strengthening timber structures by means of composite bars. This article presents the results of preliminary tests carried out on solid beams made of fir wood.
Justyna Dygas, Michał Marcin Bakalarz, Paweł Grzegorz Kossakowski   +2 more
doaj   +1 more source

A Sinicized World Religion?: Chinese Christianity at the Contemporary Moment of Globalization

Religions, 2019
This essay explores the rise of Protestant Christianity at the contemporary stage of China’s globalization as a unique social and cultural phenomenon.
Nanlai Cao
doaj   +1 more source

Should practical usefulness be considered for theory building in HRD? Traditional versus pragmatism approach. [PDF]

Qual Quant, 2022
Mumtaz S.
europepmc   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Transforming a Heritage Building into a Living Laboratory: A Case Study of Monitoring

Energies
This paper investigates integrating a sensory data model for managing an existing 50-year-old building. A primary challenge in retrofitting older structures is the optimal deployment of high-quality sensors, systematic data acquisition, and subsequent ...
Carlos Naya, Sara Dorregaray-Oyaregui, Fernando Alonso, Juan Luis Roquette, Jose María Yoldi, César Martín-Gómez   +5 more
doaj   +1 more source

Extending Blatt's two-polarity model of personality development to dissociative identity disorder: a theory-building case study. [PDF]

Res Psychother, 2021
Cornelis S, Desmet M, Meganck R, Van Nieuwenhove K, Willemsen J.   +4 more
europepmc   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Numerical and Theoretical Analyses of Laminated Veneer Lumber Beams Strengthened with Fiber-Reinforced Polymer Sheets

Applied Sciences
This study outlines a method of utilizing the finite element method and a simple mathematical model to predict the behavior of laminated veneer lumber (LVL) beams strengthened with composite sheets. The numerical models were created using the Abaqus 2017
Michał Marcin Bakalarz, Paweł Grzegorz Kossakowski   +1 more
doaj   +1 more source

[Evidence-based prevention and health promotion: theory building and implementation into practice]. [PDF]

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz, 2021
De Bock F, Spura A.
europepmc   +1 more source