Results 131 to 140 of about 6,774,858 (301)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Screening of α-Glucosidase Inhibitors in Cyclocarya paliurus Extracts Based on Affinity Ultrafiltration-Liquid Chromatography-Mass Spectrometry Combined with Correlation Analysis

Shipin gongye ke-ji
Objective: To rapidly screen α-glucosidase inhibitors in the extract of Cyclocarya paliurus, the affinity ultrafiltration-liquid chromatography-mass spectrometry technique combined with correlation analysis were used to explore the relationship between ...
Zude CHEN, Boji MA, Yan XIAO, Rengeng SHU, Bingtao LI, Li JIANG, Guoliang XU, Qiyun ZHANG   +7 more
doaj   +1 more source

Theory development. What theory is not

, 2003
Este ensaio descreve as diferenças entre artigos que possuem alguma teoria dos que não possuem teoria. Há pouco acordo sobre o que constitui uma teoria forte versus uma teoria fraca nas Ciências Sociais, mas há mais consenso sobre o fato de que referências, dados, variáveis, diagramas e hipóteses não são teoria.
Sutton, Robert I., Staw, Barry
openaire   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Trialogical cooperation for urban transformation: key relations for enhancing transformative governance

Urban Transformations
Urban transformations towards sustainability require cooperation among various stakeholders. There is an increasing amount of research on how to facilitate these cooperations, particularly regarding necessary governance modes and capacities.
Laura Brings, Agnes Förster, Matthias Wanner   +2 more
doaj   +1 more source

Qualitative futuring methods in communicative (inter)action: Exploring the development and deployment of the Future Synthesizer method

Societal Impacts
This contribution presents initial efforts to respond to the question: How do qualitative futuring methods enhance the design of participatory processes for regional and urban planning? This work makes use of futuring approaches and methods to help build
Agnes Förster, Robin A. Chang, Katja Schotte   +2 more
doaj   +1 more source

Towards the Development of a Taxonomic Theory.

, 2015
Developing IS theories has been an important goal for many IS researchers. Towards that end, we discuss how taxonomic theory can be developed. According to Gregor, taxonomic theories are theories for analyzing, which she classifies as Type I Theory. More specifically, we show that some taxonomies, after meeting some conditions, can lead to taxonomic ...
Muntermann, Jan, Nickerson, Robert, Varshney, Upkar   +2 more
openaire   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Advanced Thermionic Technology Program [PDF]

Topics include surface studies (surface theory, basic surface experiments, and activation chamber experiments); plasma studies (converter theory and enhanced mode conversion experiments); and component development (low temperature conversion experiments,

core   +1 more source