Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
The Hierarchy-of-Hypotheses Approach: A Synthesis Method for Enhancing Theory Development in Ecology and Evolution. [PDF]
Bioscience, 2021 Heger T +16 more
europepmc +1 more source
The IDB: Vol. 24, no. 11, November 1997
, 1997 The IDB reports on economic and social development trends in Latin America and the Caribbean and on the activities of the Bank.
Inter-American Development Bank
core +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
CARING FUTURES: a study protocol for transdisciplinary qualitative research on technology-mediated care practices and theory development for ethics of care. [PDF]
BMJ Open, 2021 Ramvi E +4 more
europepmc +1 more source
The IDB: Vol. 24, no. 9-10, September-October 1997
, 1997 The IDB reports on economic and social development trends in Latin America and the Caribbean and on the activities of the Bank.
Inter-American Development Bank
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Understanding the Latent Structure of Dynamic Risk: Seeking Empirical Constraints on Theory Development Using the VRS-SO and the Theory of Dynamic Risk. [PDF]
Sex Abuse, 2022 Olver ME +2 more
europepmc +1 more source
Theory development. What theory is not
, 2003 Este ensaio descreve as diferenças entre artigos que possuem alguma teoria dos que não possuem teoria. Há pouco acordo sobre o que constitui uma teoria forte versus uma teoria fraca nas Ciências Sociais, mas há mais consenso sobre o fato de que referências, dados, variáveis, diagramas e hipóteses não são teoria.
Sutton, Robert I., Staw, Barry
openaire +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source