Results 161 to 170 of about 6,774,858 (301)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

A Systematic Review of Aphantasia: Concept, Measurement, Neural Basis, and Theory Development. [PDF]

Vision (Basel)
Jin F, Hsu SM, Li Y.
europepmc   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Conceptualising nursing theory and practice within a local cultural and professional context: a methodological example to inform theory development. [PDF]

J Res Nurs
Pagnucci N, Tolotti A, Valcarenghi D, Carnevale F, Sasso L, Bagnasco A.   +5 more
europepmc   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Commentary: Conceptualising nursing theory and practice within a local cultural and professional context: a methodological example to inform theory development. [PDF]

J Res Nurs
White M.
europepmc   +1 more source

Programme theory development and formative evaluation of a provincial knowledge translation unit. [PDF]

Health Res Policy Syst, 2019
Thomson D, Brooks S, Nuspl M, Hartling L.   +3 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Theory development of under what circumstances and what works for promoting disaster preparedness among long-term care facility (LTCF) stakeholders: protocol for realist review. [PDF]

BMJ Open
Mitani S, Ogawara H, Miyagawa S, Doorenbos AZ, Fukahori H.   +4 more
europepmc   +1 more source

Advancing theory development: exploring the leadership-climate relationship as a mechanism of the implementation of cultural competence. [PDF]

Implement Sci, 2017
Guerrero EG, Fenwick K, Kong Y.
europepmc   +1 more source