Results 51 to 60 of about 1,891,682 (295)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Critical dynamical heterogeneities close to continuous second-order glass transitions

, 2014
We analyse, using Inhomogenous Mode-Coupling Theory, the critical scaling behaviour of the dynamical susceptibility at a distance epsilon from continuous second-order glass transitions. We find that the dynamical correlation length xi behaves generically
Biroli, Giulio, Bouchaud, Jean-Philippe, Miyazaki, Kunimasa, Nandi, Saroj Kumar, Reichman, David R.   +4 more
core   +3 more sources

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Quantum structural phase transition in chains of interacting atoms

, 2010
A quasi one--dimensional system of trapped, repulsively interacting atoms (e.g., an ion chain) exhibits a structural phase transition from a linear chain to a zigzag structure, tuned by reducing the transverse trap potential or increasing the particle ...
Fishman, Shmuel, Morigi, Giovanna, Shimshoni, Efrat   +2 more
core   +1 more source

On the multiaxial fatigue assessment of complex three-dimensional stress concentrators [PDF]

, 2014
This paper assesses and quantifies the detrimental effects of complex tri-dimensional notches subjected to uniaxial and multiaxial fatigue loading. A number of experimental results taken from the technical literature and generated by testing specimens ...
ASKES, Harm, DRAPER, John, GERIN, Benjamin, LOUKS, Richard, SUSMEL, Lucas   +4 more
core   +6 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Contextualism in Normative Political Theory and the Problem of Critical Distance [PDF]

Ethical Theory and Moral Practice, 2019
Political theory is contextualist when factual claims about context are part of the justification of normative political judgments. There are different kinds of contextualism depending on whether context is relevant for the formulation and justification of political principles (methodological contextualism), whether principles themselves are ...
openaire   +1 more source

Geometrical Properties of Conformal Field Theories Coupled to Two-Dimensional Quantum Gravity

, 1994
In this work we discuss an approach due to F. David to the geometry of world sheets of non-critical strings in quasiclassical approximation. The gravitational dressed conformal dimension is related to the scaling behavior of the two-point function with ...
Berlin, HU, Braune, S.
core   +1 more source

Sine-Gordon/Coulomb Gas Soliton Correlation Functions and an Exact Evaluation of the Kosterlitz-Thouless Critical Exponent [PDF]

, 2004
We present an exact derivation for the asymptotic large distance behavior of the spin two-point correlation function in the XY-model. This allows for the exact obtainment of the critical exponent $\eta=1/4$ at the Kosterlitz-Thouless transition that ...
A. Alastuey, A. Lima-Santos, A. Luther, A. M. Tsvelik, C. Destri, D. J. Amit, E. C. Marino, E. C. Marino, G. Arfken, J. M. Kosterlitz, J. V. José, J.M. Kosterlitz, L. Samaj, L. Samaj, L. Samaj, Leonardo Mondaini, P. J. Forrester, P. Kalinay, P. Minnhagen, S. Coleman, S. Lukyanov, S. Lukyanov, S. Mandelstam, S. Samuel, T. Giamarchi   +24 more
core   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source