Results 61 to 70 of about 185,127 (293)

The effect of notch size on critical distance and fatigue life predictions

Materials & Design, 2020
Notch and size effects generally show great influence on the fatigue behavior of engineering structures, which plays a vital role during their structural integrity and reliability evaluations.
Shun-Peng Zhu, Jin-Chao He, Ding Liao, Qingyuan Wang, Yongjie Liu   +4 more
doaj   +1 more source

Some Applications of Critical Point Theory of Distance Functions on Riemannian Manifolds [PDF]

Compositio Mathematica, 2002
In this paper, we use the theory of critical points of distance functions to study the rigidity and topology of Riemannian manifolds with sectional curvature bounded below. We prove that an n -dimensional complete connected Riemannian manifold M with ...
openaire   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Promoting reflection in asynchronous virtual learning spaces: tertiary distance tutors’ conceptions. [PDF]

, 2014
Increasingly, universities are embedding reflective activities into the curriculum. With the growth in online tertiary education, how effectively is reflection being promoted or used in online learning spaces?
Richardson, John T. E., Linda Price, Price, Linda, Richardson, John T E, John T. E. Richardson, Bethany Alden Rivers, Alden Rivers, Bethany   +6 more
core   +1 more source

Performance of Convolution Codes Based on 60 GHz Inter-Chip Wireless Interconnection System

Dianxin kexue, 2015
In order to solve reliability problem in 60 GHz inter-chip wireless interconnection system，the performance of convolution codes was studied from the view of coding gain and energy consumption.
Xuehua Li, Siyu Shen, Yafei Wang
doaj   +2 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Dual-Dimensional Digital Transformation Systematically Reshapes the U-Curve of Knowledge and Political Distance on Subsidiary Exit

Systems
In the era of digital business model innovation, multinational corporations face a dual challenge: leveraging digital technologies to overcome institutional barriers while reconfiguring value creation in cross-border operations. Grounded in institutional
Zhengyuan Zhou, Lei Wang
doaj   +1 more source

Nicolai Hartmanns Critical Ontology and the Critical Realism of the Berlin School of Gestalt Psychology

Gestalt Theory, 2019
The author exemplifies the congruency of essential foundations between the critical realism of the Berlin School of Gestalt Psychology (Gestalt theory) and Nicolai Hartmann’s Critical Ontology.
Walter Hans-Jürgen P.
doaj   +1 more source

Adaptive Metrics for Adaptive Samples

Algorithms, 2020
We generalize the local-feature size definition of adaptive sampling used in surface reconstruction to relate it to an alternative metric on Euclidean space.
Nicholas J. Cavanna, Donald R. Sheehy
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source