Results 91 to 100 of about 3,953,601 (297)

How to Prevent Catheter-Associated Urinary Tract Infections: A Reappraisal of Vico's Theory-Is History Repeating Itself? [PDF]

J Clin Med, 2022
Musco S, Giammò A, Savoca F, Gemma L, Geretto P, Soligo M, Sacco E, Del Popolo G, Li Marzi V.   +8 more
europepmc   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Operability, Multiscalarity, Diversity, and Complexity in the UNESCO Heritage Regulatory Framework

Buildings
The historical genealogy of the heritage regulatory framework, spanning from the 20th century to the present day, provides insights into the continuous socio-cultural transformations within communities.
Adrián Rodríguez-Segura, Mar Loren-Méndez, José María Galán-Conde   +2 more
doaj   +1 more source

Comparative media history, an introduction: 1789 to the present [PDF]

, 2005
This book aims to give a greater insight into the modern history of the media by considering influences on developments within a framework that uses a comparative approach to weigh up continuity versu change.
Chapman, Jane
core  

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Ethical acceptability of telemedicine: Nursing home resident's perspective on telemedical consultations

Digital Health
Objective The use of telemedicine in health care has recently expanded, and with it the need to evaluate its use from an ethical perspective. Studies investigating the ethical acceptability of telemedical consultations (TC) in nursing homes are lacking ...
Nataliya Sira, Dominik Groß, , Saskia Wilhelmy   +3 more
doaj   +1 more source

Competencies on sustainability and blue entrepreneurship in university guides: the challenge of a truly blue economy

Cogent Education
The inclusion of competences related to sustainability and blue entrepreneurship aligns with the 2030 Agenda, a global framework adopted by the United Nations to promote sustainability through 17 Sustainable Development Goals (SDGs).
Miguel-Ángel Fernández-Jiménez, Lourdes Aranda, Esther Mena-Rodríguez   +2 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The importance of multi-roles and code-switching in living labs

Buildings & Cities
The challenges and opportunities for multi-roles in participatory urban development projects are investigated. An analysis of bottom-up initiatives in two living labs in Germany: Quartier:PLUS (Braunschweig) and Österreichischer Platz (Stuttgart ...
Hanna Noller, Ayat Tarik
doaj   +1 more source