Results 71 to 80 of about 599,254 (318)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Autism in flux: A history of the concept from Leo Kanner to DSM-5 [PDF]
, 2013 In this paper, I argue that a new relation between past and present – a supposed historical continuity in the meaning of autism – is created by the histories written by the discipline itself. In histories of autism written by ‘practitioner-historians’, a
Verhoeff, Berend
core +1 more source
Dialogues in Clinical Neuroscience, 2007 Whether every effect can be precisely linked to a given cause or to a list of causes has been a matter of debate for centuries, particularly during the 17th century, when astronomers became capable of predicting the trajectories of planets. Recent mathematical models applied to physics have included the idea that given phenomena cannot be predicted ...
openaire +3 more sources
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
States of Exception: Law, History, Theory
, 2020 This book addresses the relevance of the state of exception for the analysis of law, while reflecting on the deeper symbolic and jurisprudential significance of the coalescence between law and force.
core
Philosophy, Ethics, and Humanities in Medicine, 2022 Background The West African Ebola virus epidemic from 2014 to 2016 is unprecedented in its scale, surpassing all previous and subsequent Ebola outbreaks since 1976.
Saskia Wilhelmy +2 more
doaj +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Urban PlanningThe emergence of urban care communities has recently become a topic of study, with a focus on the social bonds shaped through mutual assistance and support in vulnerable and non‐vulnerable neighbourhoods following natural disasters, pandemic situations ...
Rosa M. de la Fuente, Lucía Cobos
doaj +1 more source