Results 141 to 150 of about 599,254 (318)
The Strong and Weak Senses of Theory-Ladenness of Experimentation: Theory-Driven versus Exploratory Experiments in the History of High-Energy Particle Physics [PDF]
, 2012 In the theory-dominated view of scientific experimentation, all relations of theory and experiment are taken on a par; namely, that experiments are performed solely to ascertain the conclusions of scientific theories.
Karaca, Koray
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Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
WHAT IS HISTORY IN A SETTLER COLONIAL SOCIETY? MAPPING THE LIMITS AND POSSIBILITIES OF ETHICAL HISTORIOGRAPHY USING AN AUSTRALIAN CASE STUDY [PDF]
In recent decades, the role of the history discipline as part of the architecture of colonization has become more visible and better understood.
Clark, A
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Divisions, Areas, and Ensembles - Music History Theory Ethnomusicology
, 2014 Photograph of a Faculty/Staff Group Photo for Music History, Theory, and ...
University of North Texas. College of Music.
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Mainstream Consumer Theory: Delay, Acceptance and History Texts
Consumer theory is considered to be the hard core of the neoclassical canon. The present work traces the various historical stages which led to the acceptance of the theory, and attempts to offer some possible explanations for its eventual establishment.
Karayiannis, Anastassios +1 more
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Introduction: Toward a history of Soviet and post-Soviet literary theory and criticism
, 2011 Introduction: Toward a history of Soviet and post-Soviet literary theory and ...
Dobrenko E., Tihanov G.
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