Results 61 to 70 of about 3,954,011 (294)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

Identifying the scope of ethical challenges caused by the Ebola epidemic 2014-2016 in West Africa: a qualitative study

open access: yesPhilosophy, Ethics, and Humanities in Medicine, 2022
Background The West African Ebola virus epidemic from 2014 to 2016 is unprecedented in its scale, surpassing all previous and subsequent Ebola outbreaks since 1976.
Saskia Wilhelmy   +2 more
doaj   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

open access: yesFEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang   +5 more
wiley   +1 more source

Theories of History

open access: yes, 2018
In a unique approach to historical representations, the central question of this book is “what is history?” By describing “history” through its supplementary function to the field of history, rather than the ground of a study, this collection considers new insights into historical thinking and historiography across the humanities. It fosters engagement
Kelly, Michael J., Rose, Arthur
openaire   +2 more sources

Kuhn Losses Regained: Van Vleck from Spectra to Susceptibilities [PDF]

open access: yes, 2012
We follow the trajectory of John H. Van Vleck from his 1926 Bulletin for the National Research Council (NRC) on the old quantum theory to his 1932 book, The Theory of Electric and Magnetic Susceptibilities.
Janssen, Michel, Midwinter, Charles
core   +2 more sources

Symmetries of Decoherence Functionals [PDF]

open access: yes, 1996
The basic ingredients of the `consistent histories' approach to quantum theory are a space $\UP$ of `history propositions' and a space $\D$ of `decoherence functionals'. In this article we consider such history quantum theories in the case where $\UP$ is
Schreckenberg, S.
core   +2 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

open access: yesFEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

open access: yesFEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang   +8 more
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Telemedicine in nursing homes: Insights on the social acceptance and ethical acceptability of telemedical consultations

open access: yesDigital Health, 2023
Introduction The increasing number of older adults in need of care, the resulting rise in demand for care services and the shortage of nursing staff are major challenges for society.
Julia Offermann   +5 more
doaj   +1 more source

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