Results 61 to 70 of about 3,953,601 (297)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Identifying the scope of ethical challenges caused by the Ebola epidemic 2014-2016 in West Africa: a qualitative study

Philosophy, Ethics, and Humanities in Medicine, 2022
Background The West African Ebola virus epidemic from 2014 to 2016 is unprecedented in its scale, surpassing all previous and subsequent Ebola outbreaks since 1976.
Saskia Wilhelmy, Regina Müller, Dominik Gross   +2 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Theories of History

, 2018
In a unique approach to historical representations, the central question of this book is “what is history?” By describing “history” through its supplementary function to the field of history, rather than the ground of a study, this collection considers new insights into historical thinking and historiography across the humanities. It fosters engagement
Kelly, Michael J., Rose, Arthur
openaire   +2 more sources

Fatal attraction: a critique of Carl Schmitt's international political and legal theory [PDF]

, 2011
The ongoing Schmitt revival has extended Carl Schmitt's reach over the fields of international legal and political theory. Neo-Schmittians suggest that his international thought provides a new reading of the history of international law and order, which ...
Agamben, Anderson, Anderson, Balakrishnan, Bendersky, Benno Gerhard Teschke, Bonney, Brenner, Brewer, Brewer, Brown, Cocker, Colas, De Benoist, Diner, Diner, Downing, Fisch, Gowan, Habermas, Habermas, Haggenmacher, Hardt, Holmes, Joerges, Kelsen, Kervégan, Kunisch, Körner, Lilla, Marx, Mehring, Miller, Mouffe, Mouffe, Mouffe, Müller, O'Brien, Odysseos, Odysseos, Odysseos, Ojakangas, Opitz, Parker, Petito, Rasch, Repgen, Rüthers, Rüthers, Scheuerman, Scheuerman, Scheuerman, Schmitt, Schmitt, Schmitt, Schmitt, Schmitt, Schmitt, Schmitt, Schmitt, Schmitt, Schmitt, Schmoeckel, Schroeder, Shapiro, Smith, Stirk, Stirk, Teschke, Tilly, Tooze, Wehler, Wolf, Wood, Wood, Wright, Zolo, Zolo, Žižek   +78 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Kuhn Losses Regained: Van Vleck from Spectra to Susceptibilities [PDF]

, 2012
We follow the trajectory of John H. Van Vleck from his 1926 Bulletin for the National Research Council (NRC) on the old quantum theory to his 1932 book, The Theory of Electric and Magnetic Susceptibilities.
Janssen, Michel, Midwinter, Charles
core   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Telemedicine in nursing homes: Insights on the social acceptance and ethical acceptability of telemedical consultations

Digital Health, 2023
Introduction The increasing number of older adults in need of care, the resulting rise in demand for care services and the shortage of nursing staff are major challenges for society.
Julia Offermann, Martina Ziefle, Nataliya Sira, Dominik Groß, , Saskia Wilhelmy   +5 more
doaj   +1 more source