Results 131 to 140 of about 1,076,493 (308)
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Literature, in Theory Tropes, Subjectivities, Responses and Responsibilities
Intro -- Contents -- Acknowledgements -- Foreword, in Lieu of an Introduction -- 1 Toward a Phenomenology of Urban Gothic: The Example of Dickens -- 2 Houses, Homes, Rooms and Tombs: The Unhomely Spaces and Monstrous Economies of Dombey and Son -- 3 In ...
Wolfreys, Julian.
core
Games, literature and imagination [PDF]
, 2015 The game world has recently been experiencing a renaissance of games that lean strongly on the use of text to communicate their worlds, characters and events.
Electronic Literature Organization 2015 : The End(s) of Electronic Literature +1 more
core
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Postklasična teorija pripovedi
Slavistična Revija, 2013 Postklasična teorija pripovedi je poimenovanje za naratologijo v zadnjih treh desetletjih - to poimenovanje pa si zasluži samo tista naratologija, ki je odstopila svoje tradicionalno poslanstvo polivalentni teoriji pripovedovanja in tako premestila svoj ...
Alojzija Zupan Sosič
doaj
Contemporary children's literature and film : engaging with theory
, 2011 Bringing together the voices of leading and emerging scholars, this book provides critical approaches for reading children's literature and film. It argues for the significance of theory for reading texts written and produced for young people and ...
Mallan, Kerry M. +3 more
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YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
A grand unified theory of trust
Trust is a vital, yet nebulous philosophical concept which has persistently defied singular definition despite undergoing millennia of research scrutiny.
Archer, Matthew Christopher
core +1 more source