Results 51 to 60 of about 2,808,238 (335)

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Social Cognition and Theory of Mind

Neuropsychiatric Investigation
For an individual to exist in a society, they must be receptive to not only signals from their natural environment but also to those from their social environment.
Miray Atacan Yaşgüçlükal, Ayşe Deniz Elmalı, Barış Korkmaz   +2 more
doaj   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Theory of Mind: Development, Neurobiology, Related Fields and Neurodevelopmental Disorders [PDF]

Psikiyatride Güncel Yaklaşımlar, 2019
Theory of mind is a social cognition skills demonstrated its importance in the last forty years with psychiatric clinical trials. Theory of mind is seen as an effective and necessary skill in the social function-ing of human who is a social creature as ...
Berkan Sahin, Abdullah Bozkurt, Miraç Baris Usta, Muazzez Aydin, Cansu Cobanoglu, Koray Karabekiroglu   +5 more
doaj   +1 more source

The Origins of Theory of Mind in Infant Social Cognition: Investigating Longitudinal Pathways from Intention Understanding and Joint Attention to Preschool Theory of Mind [PDF]

, 2022
Amanda C. Brandone, Wyntre Stout
openalex   +1 more source

Metakognisi Dan Theory of Mind (ToM) [PDF]

, 2011
This article is a literature review on the relationship between Metacognition and Theory of Mind (ToM). Metacognition refers to the superordinat concept consisting of at least two components, namely (1) knowledge, (2) monitoring (experience) and ...
Murti, H. A. (Heru)
core  

Network Localization of Fatigue in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Fatigue is among the most common symptoms and one of the main factors determining the quality of life in multiple sclerosis (MS). However, the neurobiological mechanisms underlying fatigue are not fully understood. Here we studied lesion locations and their connections in individuals with MS, aiming to identify brain networks ...
Olli Likitalo, Jaakko Kungshamn, Albert Bellmunt‐Gil, Silvia Tommasin, Abhineet Ojha, Matias Viitala, Juho Aaltonen, Jyrki Lötjönen, Juha Koikkalainen, Pauli Ylikotila, Patrizia Pantano, Merja Soilu‐Hänninen, Juho Joutsa   +12 more
wiley   +1 more source

How to Make Correct Predictions in False Belief Tasks without Attributing False Beliefs: An Analysis of Alternative Inferences and How to Avoid Them

Philosophies, 2018
The use of new paradigms of false belief tasks (FBT) allowed to reduce the age of children who pass the test from the previous 4 years in the standard version to only 15 months or even a striking 6 months in the nonverbal modification.
Ricardo Augusto Perera, Sofia Inês Albornoz Stein   +1 more
doaj   +1 more source