Results 81 to 90 of about 131,631 (317)

Socio-technical analysis of system-of-systems using responsibility modelling [PDF]

open access: yes, 2012
Society is challenging systems engineers by demanding increasingly complex and integrated IT systems (Northrop et al., 2006; RAE, 2004) e.g. integrated enterprise resource planning systems, integrated healthcare systems and business critical services ...
Greenwood, David
core  

Quantitatively Measure Access Control Mechanisms Across Different Operating Systems [PDF]

open access: yes, 2013
Access control mechanisms (ACM) play a critical role in protecting operating systems from malicious attacks. A variety of ACMs have been proposed till date, including discretionary access control (DAC) and mandatory access control (MAC).
Zhang, Yang   +5 more
core   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

open access: yesMolecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard   +8 more
wiley   +1 more source

Operating room planning and scheduling: A literature review. [PDF]

open access: yes
This paper provides a review of recent research on operating room planning and scheduling. We evaluate the literature on multiple fields that are related to either the problem setting (e.g.
Belien, Jeroen   +2 more
core  

Parametric identification of linear systems operating under feedback control [PDF]

open access: yes, 2001
This paper considers the indirect identification of closed-loop systems with colored noise when low-order controllers exist in the loop. A new form of bias-eliminated least-squares (BELS) method is developed which is based on a simple and efficient ...
Zheng, Wei Xing
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach   +9 more
wiley   +1 more source

Developing a multi-methodological approach to hospital operating theatre scheduling [PDF]

open access: yes, 2014
Operating theatres and surgeons are among the most expensive resources in any hospital, so it is vital that they are used efficiently. Due to the complexity of the challenges involved in theatre scheduling we split the problem into levels and address the
Penn, Marion Louise
core  

Structural Determinants of Criticality in Biological Networks

open access: yesFrontiers in Physiology, 2015
Many adaptive evolutionary systems display spatial and temporal features, such as long-range correlations, typically associated with the critical point of a phase transition in statistical physics. Empirical and theoretical studies suggest that operating
Sergi eValverde   +6 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

open access: yesMolecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant   +7 more
wiley   +1 more source

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