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Updating democracy studies: outline of a research program [PDF]

open access: yes, 2012
Technologies carry politics since they embed values. It is therefore surprising that mainstream political and legal theory have taken the issue so lightly.
Mindus, Patricia
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

The Ideology Critique of Mearsheimer’s Theory of Offensive Neorealism: The Case of Russia-Ukraine War and Its Ideologization in Indonesia

open access: yesJournal of Global Strategic Studies, 2022
This article examines the ideology critique of Mearsheimer’s theory of offensive neorealism because his theory preoccupies the reality of world politics, especially in the Russia-Ukraine War case.
Musa Maliki, Dini Putri Saraswati
doaj   +1 more source

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

open access: yesFEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

Multispecies justice: theories, challenges, and a research agenda for environmental politics

open access: yesEnvironmental Politics, 2020
This essay seeks to open a conversation about multispecies justice in environmental politics. It sets out some of the theoretical approaches, key areas of exploration, and obvious challenges that come with rethinking a core plank of liberal theory and ...
D. Celermajer   +7 more
semanticscholar   +1 more source

Long‐term culture of skin biopsies: maintenance of fibroblast production and competency of reprogramming

open access: yesFEBS Open Bio, EarlyView.
Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar   +3 more
wiley   +1 more source

FEMINIST INTERPRETATIONS OF ACTION AND THE PUBLIC IN HANNAH ARENDT’S THEORY

open access: yesStudia Universitatis Babeș-Bolyai. Philosophia, 2020
Feminist Interpretations of Action and the Public in Hannah Arendt’s Theory. Arendt’s typology of human activity and her arguments on the precondition of politics allow for a variety in interpretations for contemporary political thought.
Noémi BÍRÓ
doaj   +1 more source

Neopatrimonialism in the 2020 Regional Head Elections in the Power Cube Perspective

open access: yesBestuurskunde, 2021
The number of candidates who have a kinship with political and/or government entities in the 2020 Pilkada in Indonesia has shot up compared to the previous period, namely originally 59 candidates (2005-2014 period), 86 candidates (2015-2018 period), now
Muhammad Aqiel, Ananda Putri Sujatmiko
doaj   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

open access: yesFEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp   +13 more
wiley   +1 more source

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