Results 51 to 60 of about 6,497 (256)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Hundres Years of Theory of Relativity
Advances in Electrical and Electronic Engineering, 2005 In 2005, all civilised worl will remind the 100 years anniversary of Publishing the original work on special theory of relativity by Albert Einstein. This contribution is a brief review of its principial ideas in the field of electrodynamics.
Jaroslav Franek
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Charged black hole and radiating solutions in entangled relativity
European Physical Journal C: Particles and Fields, 2021 In this manuscript, we show that the external Schwarzschild metric can be a good approximation of exact black hole solutions of entangled relativity.
Olivier Minazzoli, Edison Santos
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FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Lacunae in the philosophical foundations of special relativity
Open AstronomyBased on the two postulates of the invariance of both the laws of physics and light speed in inertial frames, Einstein revolutionised the prevalent conceptions of space and time in the Special Theory of Relativity, which is not however without ...
Debono Franco
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Relative Cohomology of Algebraic Theories [PDF]
Applied Categorical Structures, 2016 7 pages, latex, v.2 accepted in Applied Categorical ...
openaire +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Teaching general relativity theory in high school: why, what and how
Revista de Enseñanza de la Física, 2017 In this work, which is part of a wider research, the problem of teaching the General Theory of Relativity in sec-ondary school is addressed, even though this theory is scarcely addressed even in physics degree courses.
Irene Arriassecq +2 more
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