Results 61 to 70 of about 4,380 (214)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
How quantum theory helps us explain [PDF]
, 2012 I offer an account of how the quantum theory we have helps us explain the enormous variety of phenomena it is generally taken to explain. The account depends on what I have elsewhere called a pragmatist interpretation of the theory.
Healey, Richard
core
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
Exploring the translation strategies in scientific texts: a case study of 30-second forensic science
, 2023 The capstone project focuses on the complex and nuanced process of scientific translation, examining the strategies employed to ensure accuracy and accessibility of scientific texts.
Xia, Yiyi
core
European Journal of Histochemistry, 2009 One of the most sacred freedom in the scientific world is the freedom to challenge: to test new ideas against old, established ones, to try and explain facts and results by means of new interpretations, sometimes even to believe the unbelievable ...
M Biggiogera
doaj +1 more source
FEBS Open Bio, EarlyView.This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel +4 more
wiley +1 more source
Putting Pragmatism to Work in the Cold War: Science, Technology, and Politics in the Writings of James B. Conant [PDF]
, 2011 This paper examines James Conant’s pragmatic theory of science – a theory that has been neglected by most commentators on the history of 20th-century philosophy of science – and it argues that this theory occupied an important place in Conant’s strategic
Justin Biddle, Biddle, Justin B.
core +1 more source
FEBS Open Bio, EarlyView.Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao +3 more
wiley +1 more source
Basics of English-Ukrainian translation in an intercultural educational environment
Acta Academiae Beregsasiensis, PhilologicaThe article covers the study of the basics of English -Ukrainian translation in the intercultural educational environment of Transcarpathia. The concepts of bilingual and trilingual education in institutions of higher education are defined as well as ...
Oleksandr Ostrovsky, Kurt A. Stahura
doaj +1 more source