Results 111 to 120 of about 176,595,669 (299)

Theory In, Theory Out: The Uses of Social Theory in Machine Learning for Social Science. [PDF]

Front Big Data, 2020
Radford J, Joseph K.
europepmc   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Theories or No Theories—Is Anything Evolving?

Cambridge Quarterly of Healthcare Ethics, 2023
Takala, Tuija, Häyry, Matti
openaire   +3 more sources

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

“Nondualism is philosophy, not ethnography”: A review of the 2011 GDAT debate

, 2012
The motion for the 2011 Group Debate in Anthropological Theory (GDAT), which took place at the University of Manchester (on November 12, 2011) was “Nondualism is philosophy, not ethnography”. Nondualism as a philosophical term entails continuity between
Kyriakides, Theodoros, The Group for Debates in Anthropological Theory (GDAT): A brief introduction, Foreword by Soumhya Venkatesan,   +1 more
core   +1 more source

Enhanced acoustic monitoring for industrial predictive maintenance using semi-coprime microphone array and joint spatial-frequency filtering

EURASIP Journal on Audio, Speech, and Music Processing
This paper analyzes the problem of the acquisition and separation of sound sources in industrial environments that concentrate the energy in different frequency bands, using microphone arrays.
Gonzalo Corral-García, Diana Tejera-Berengué, Manuel Utrilla-Manso, Manuel Rosa-Zurera, Roberto Gil-Pita, FangFang Zhu-Zhou   +5 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Introduction to Risk Theory

, 2012
Risk is an important topic in contemporary society. People are confronted with risks from financial markets, nuclear power plants, natural disasters and privacy leaks in ICT systems, to mention just a few of a sheer endless list of areas in which ...
Sveriges lantbruksuniversitet., Sandin, Per,   +1 more
core   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source