Results 101 to 110 of about 47,521 (285)

Hypoglycemic and hypolipidemic bioactive compounds from edible traditional Chinese medicines and their action of mechanisms explored by multitarget affinity ultrafiltration with liquid chromatography–mass spectrometry

Food Frontiers
Edible traditional Chinese medicines (TCMs) have a long‐standing history in tackling obesity, diabetes, and metabolic diseases, which, in turn, significantly promotes the exploration of functional food products derived from edible TCMs with lower ...
Xiaowen Hua, Mengjia Xu, Ming Yang, Yingying Zhang, Jianke Ma, Li Cheng, Chu Chu, Zimiao Wu, Mingquan Guo   +8 more
doaj   +1 more source

Peptide–Drug Conjugates as Next-Generation Therapeutics: Exploring the Potential and Clinical Progress

Bioengineering
Peptide–drug conjugates (PDCs) have emerged as a next-generation therapeutic platform, combining the target specificity of peptides with the pharmacological potency of small-molecule drugs.
Krishna Jadhav, Ashwin Abhang, Eknath B. Kole, Dipak Gadade, Apurva Dusane, Aditya Iyer, Ankur Sharma, Saroj Kumar Rout, Amol D. Gholap, Jitendra Naik, Rahul K. Verma, Satish Rojekar   +11 more
doaj   +1 more source

Carbon Nano-Allotrope/Magnetic Nanoparticle Hybrid Nanomaterials as T2 Contrast Agents for Magnetic Resonance Imaging Applications

Journal of Functional Biomaterials, 2018
Magnetic resonance imaging (MRI) is the most powerful tool for deep penetration and high-quality 3D imaging of tissues with anatomical details. However, the sensitivity of the MRI technique is not as good as that of the radioactive or optical imaging ...
Yunxiang Gao
doaj   +1 more source

Gold nanoparticles enlighten the future of cancer theranostics [PDF]

, 2017
Development of multifunctional nanomaterials, one of the most interesting and advanced research areas in the field of nanotechnology, is anticipated to revolutionize cancer diagnosis and treatment. Gold nanoparticles (AuNPs) are now being widely utilized
Guo, Jianfeng, He, Yan, Holmes, Justin D., Li, Lin-Lin, O'Driscoll, Caitríona M., Rahme, Kamil   +5 more
core   +2 more sources

In Situ Lipoprotein‐seeking Dye for in Vivo Real‐Time Imaging of Lipid Dysregulation Diseases

Advanced Science, EarlyView.
This study develops lipoprotein‐seeking NIR‐II dyes that specifically bind circulating lipoproteins. These dyes form ultra‐stable complexes with endogenous lipoprotein, enabling real‐time, high‐contrast imaging of fatty liver and atherosclerotic plaques. Tunable binding kinetics allow customized imaging windows.
Yijing Du, Zetao Dang, Baofeng Xu, Jiajun Xu, Dan Wang, Yuewei Zhang, Shoujun Zhu   +6 more
wiley   +1 more source

Integrin-Specific Stimuli-Responsive Nanomaterials for Cancer Theranostics

Pharmaceutics
Background: Cancer is one of the leading causes of death worldwide. The tumor microenvironment makes the tumor difficult to treat, favoring drug resistance and the formation of metastases, resulting in death.
Zahra Taheri, Negin Mozafari, Ghazal Moradian, Denise Lovison, Ali Dehshahri, Rossella De Marco   +5 more
doaj   +1 more source

NIR Photoregulated Theranostic System Based on Hexagonal-Phase Upconverting Nanoparticles for Tumor-Targeted Photodynamic Therapy and Fluorescence Imaging

Nanomaterials, 2020
Although photodynamic therapy (PDT) is an effective, minimally invasive therapeutic modality with advantages in highly localized and specific tumor treatments, large and deep-seated cancers within the body cannot be successfully treated due to low ...
Linlin Zhao, Jongseon Choi, Yan Lu, So Yeon Kim   +3 more
doaj   +1 more source

Allogeneic Immune Cell Perfusion Inhibits the Growth of Vascularized 3D In Vitro Tumor Models, Induces Vascular Regression and Desmoplasia, but Promotes Tumor Cell Invasion

Advanced Science, EarlyView.
This study presents a vascularized 3D tumor model to investigate immune–stromal–tumor interactions under allogeneic PBMC perfusion. While immune cells induced tumor shrinkage, they also promoted vascular regression, stromal activation, and cancer cell invasion.
Alexandra Raab, Rasika Daware, Marcelo A. Szymanski de Toledo, Oskar Weber, Dimitris Kapsokalyvas, Twan Lammers, Horst Fischer, Federica De Lorenzi, Fabian Kiessling   +8 more
wiley   +1 more source

8-Anilino-1-naphthalenesulfonate-Conjugated Carbon-Coated Ferrite Nanodots for Fluoromagnetic Imaging, Smart Drug Delivery, and Biomolecular Sensing

Pharmaceutics
Background: Superparamagnetic properties and excitation independence have been incorporated into carbon-decorated manganese ferrite nanodots (MnFe@C) to introduce an economical and safer multimodal agent for use in both T1-T2 MRI and fluorescence-based ...
Anbazhagan Thirumalai, Koyeli Girigoswami, Alex Daniel Prabhu, Pazhani Durgadevi, Venkatakrishnan Kiran, Agnishwar Girigoswami   +5 more
doaj   +1 more source

Cellular Uptake and Photo-Cytotoxicity of a Gadolinium(III)-DOTA-Naphthalimide Complex “Clicked” to a Lipidated Tat Peptide

Molecules, 2016
A new bifunctional macrocyclic chelator featuring a conjugatable alkynyl-naphthalimide fluorophore pendant group has been prepared and its Gd(III) complex coupled to a cell-penetrating lipidated azido-Tat peptide derivative using Cu(I)-catalysed “click ...
William I. O’Malley, Riccardo Rubbiani, Margaret L. Aulsebrook, Michael R. Grace, Leone Spiccia, Kellie L. Tuck, Gilles Gasser, Bim Graham   +7 more
doaj   +1 more source