Results 51 to 60 of about 5,021,464 (297)

A bacteriophage cocktail targeting Yersinia pestis provides strong post-exposure protection in a rat pneumonic plague model

Microbiology Spectrum
Yersinia pestis, one of the deadliest bacterial pathogens ever known, is responsible for three plague pandemics and several epidemics, with over 200 million deaths during recorded history. Due to high genomic plasticity, Y.
Paul B. Kilgore, Jian Sha, Emily K. Hendrix, Blake H. Neil, William S. Lawrence, Jennifer E. Peel, Lauren Hittle, Joelle Woolston, Alexander Sulakvelidze, Jennifer A. Schwartz, Ashok K. Chopra   +10 more
doaj   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source

Endoscopic Management of Jejunal Diverticular Bleeding: A Case Report and Systematic Review of the Literature

Case Reports in Gastrointestinal Medicine
Bleeding from a jejunal diverticulum is a rare and potentially severe condition, challenging both to diagnose and to treat. We report the case of a 56-year-old woman presenting with massive melena, who initially underwent esophagogastroduodenoscopy (EGD)
Marta Pettinelli, Benedetto Neri, Dario Biasutto, Claudia Marinaccio, Giulia Parisi, Leandro Corradino, Margareth Martino, Francesco Maria Di Matteo   +7 more
doaj   +1 more source

Clinical outcomes of modified transarterial chemoembolization vs. drug-eluting bead transarterial chemoembolization as initial treatment for single hepatocellular carcinoma: a propensity score matching analysis

Annals of Medicine
Background & aims Optimizing transarterial chemoembolization (TACE) can enhance treatment efficacy for hepatocellular carcinoma (HCC). This study compares modified TACE (M-TACE), which combines a lipiodol-based emulsion and drug-eluting beads, with drug ...
Boyang Chang, Churen Zhou, Chengcheng Liu, Luwen Mu, Mingsheng Huang, Mingjun Bai   +5 more
doaj   +1 more source

Mechanism of bisphosphonate-related osteonecrosis of the jaw (BRONJ) revealed by targeted removal of legacy bisphosphonate from jawbone using competing inert hydroxymethylene diphosphonate

eLife, 2022
Bisphosphonate-related osteonecrosis of the jaw (BRONJ) presents as a morbid jawbone lesion in patients exposed to a nitrogen-containing bisphosphonate (N-BP). Although it is rare, BRONJ has caused apprehension among patients and healthcare providers and
Hiroko Okawa, Takeru Kondo, Akishige Hokugo, Philip Cherian, Jesus J Campagna, Nicholas A Lentini, Eric C Sung, Samantha Chiang, Yi-Ling Lin, Frank H Ebetino, Varghese John, Shuting Sun, Charles E McKenna, Ichiro Nishimura   +13 more
doaj   +1 more source

Evidence‐Informed Multidisciplinary Consensus Guidance for the Psychosocial Care of Adolescents With High‐Risk Cancer: Recommendations From the Italian Association of Pediatric Hematology and Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Adolescents with high‐risk cancer face complex developmental, psychosocial, and ethical challenges that extend beyond disease‐directed treatment. Although international recommendations exist for communication, psychosocial care, pediatric palliative care, survivorship, and shared decision‐making, these have largely evolved within ...
Johanna M. C. Blom, Dorella Scarponi, Giulia Zucchetti, Teresa Perillo, Maria Montanaro, Elisa Marconi, Chiara Rutigliano, Paolo Colavero, Paola Quarello, Marina Bertolotti, Monica Cellini, Carlo Clerici, Maurizio Mascarin, Francesca Bomben, Andrea Ferrari, the expert workgroup   +15 more
wiley   +1 more source

Bridging the Loneliness Gap: Depression, Connectivity, and Isolation in Pediatric Oncology Patients and Their Peers

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Loneliness is associated with adverse physical and mental health outcomes and remains understudied in children and adolescents undergoing cancer therapy. Pediatric oncology patients may be at increased risk due to medical isolation and disruption of social networks.
Charlotte N. Stahlfeld, Scott H. Maurer, Michelle D. Watkinson, John Nury, Elise Barberis, Molly C. Mack   +5 more
wiley   +1 more source

Gelatin Sponge Particle Embolization of Spontaneously Ruptured Intrahepatic Arterial Aneurysms in a Patient with Polyarteritis Nodosa: A Case Report

대한영상의학회지, 2017
Multiple intrahepatic arterial aneurysms and spontaneous aneurysmal rupture associated with polyarteritis nodosa leading to hemoperitoneum are extremely rare occurrences, but the conditions can be life-threatening if left untreated because of the risk of
Myung Jin Seol, Kyung Hee Noh, Young Jun Kim, Doo Sung Jeon   +3 more
doaj   +1 more source

Blockade of LAG-3 Immune Checkpoint Combined With Therapeutic Vaccination Restore the Function of Tissue-Resident Anti-viral CD8+ T Cells and Protect Against Recurrent Ocular Herpes Simplex Infection and Disease

Frontiers in Immunology, 2018
Recurrent viral diseases often occur after the viruses evade the hosts' immune system, by inducing exhaustion of antiviral T cells. In the present study, we found that functionally exhausted herpes simplex virus type 1 (HSV-1) -specific CD8+ T cells ...
Soumyabrata Roy, Pierre-Grégoire Coulon, Ruchi Srivastava, Hawa Vahed, Grace J. Kim, Sager S. Walia, Taikun Yamada, Mona A. Fouladi, Vincent T. Ly, Lbachir BenMohamed, Lbachir BenMohamed, Lbachir BenMohamed   +11 more
doaj   +1 more source

Targeting matrix metalloproteases: A promising strategy for herbal medicines to treat rheumatoid arthritis

Frontiers in Immunology, 2022
As a type of metalloproteinase, matrix metalloproteinases (MMPs) can be divided into collagenase, gelatinase, stromelysins, membrane-type (MT)-MMPs and heterogeneous subgroups according to their structure and function.
Ruo-Lan Li, Hu-Xinyue Duan, Qi Liang, Yong-Liang Huang, Ling-Yu Wang, Qing Zhang, Chun-Jie Wu, Shu-Qin Liu, Wei Peng   +8 more
doaj   +1 more source