Results 81 to 90 of about 5,632,141 (320)

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

THERAPEUTIC SERIOUS GAME DESIGN GUIDELINES FOR STIMULATING COGNITIVE ABILITIES OF CHILDREN WITH SPEECH AND LANGUAGE DELAY

Journal of ICT, 2017
The creation of an effective therapeutic serious game (TSG) is highly dependent upon its design and the fundamental knowledge of the users. Furthermore, the TSG is designed for a purpose to the users by incorporating the needs of the users in all design ...
Nadia Akma Ahmad Zaki, Tengku Siti Meriam Tengku Wook, Kartini Ahmad   +2 more
doaj  

Potent Inhibition of Zika Virus Replication by Aurintricarboxylic Acid

Frontiers in Microbiology, 2019
Zika virus (ZIKV) is one of the recently emerging vector-borne viruses in humans and is responsible for severe congenital abnormalities such as microcephaly in the Western Hemisphere.
Jun-Gyu Park, Ginés Ávila-Pérez, Ferralita Madere, Thomas A. Hilimire, Aitor Nogales, Fernando Almazán, Luis Martínez-Sobrido   +6 more
doaj   +1 more source

Methods, systems, and devices for treating tinnitus with VNS pairing [PDF]

, 2014
A method of treating tinnitus comprising measuring a patient's hearing, determining the patient's hearing loss and the patient's tinnitus frequency using the measurements of the patient's hearing, programming a clinical controller with the measurements ...
Engineer, Navzer Dara, Kilgard, Michael P., Pierce, David Michael   +2 more
core   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Predicting therapeutic and aggravating drugs for hepatocellular carcinoma based on tissue-specific pathways [PDF]

arXiv, 2017
Motivation: Hepatocellular carcinoma (HCC) is a significant health problem worldwide and annual number of cases are nearly more than 700,000. However,there are few safe and effective thera-peutic options for HCC patients.Here, we propose a new approach for predicting therapeutic and aggravating drugs for HCCbased ontissue-specificpathways, which ...
arxiv  

Laminin and Integrin in LAMA2-Related Congenital Muscular Dystrophy: From Disease to Therapeutics

Frontiers in Molecular Neuroscience, 2020
Laminin-α2-related congenital muscular dystrophy (LAMA2-CMD) is a devastating neuromuscular disease caused by mutations in the LAMA2 gene. These mutations result in the complete absence or truncated expression of the laminin-α2 chain.
Pamela Barraza-Flores, Christina R. Bates, Ariany Oliveira-Santos, Dean J. Burkin   +3 more
doaj   +1 more source

Therapeutic Courts in the Alaska Court System [PDF]

, 2016
Therapeutic courts — often called “problem-solving courts” or “wellness courts” — have been a growing component of the U.S. court system since the 1990s.
Armstrong, Barbara
core  

The Relationship between Therapeutic Alliance and Service User Satisfaction in Mental Health Inpatient Wards and Crisis House Alternatives: A Cross-Sectional Study [PDF]

, 2014
Background Poor service user experiences are often reported on mental health inpatient wards. Crisis houses are an alternative, but evidence is limited.
A Faulkner, A Quirk, A Sweeney, Angela Sweeney, B Lloyd-Evans, B Lloyd-Evans, Brynmor Lloyd-Evans, C Atkisson, C Le Boutillier, D Osborn, D Polowycz, D Rose, D Rose, David Osborn, Emma Burgess, Fiona Nolan, G Livingston, H Gilburt, H Spandler, Helen Gilburt, L Bowers, L Hansson, L Howard, M Cleary, M Leamy, M Slade, Melvin G. McInnis, Mike Slade, N Morant, Nicola Morant, P Lichtenberg, R McCabe, R McCabe, R McGuire-Snieckus, RC Stenhouse, Rosemarie McCabe, S Byford, S Johnson, S Johnson, S Johnson, S Priebe, S Weich, Sarah Fahmy, SC Kim, Sonia Johnson, V Braun, VP Tilden, Zoe Fox   +47 more
core   +4 more sources

Cytoplasmic delivery of antibodies through grafting a functional single complementarity‐determining region loop

FEBS Letters, EarlyView.
We achieved cytoplasmic delivery of non‐cell‐penetrating IgGs by grafting a single functional complementarity‐determining region 1 (CDR1) from the light chain variable region (VL) of the cell‐internalizable 3D8 antibody. The engineered IgG acquired cell‐penetrating ability while maintaining antigen affinity, highlighting CDR1 grafting as a promising ...
Yerin Jeon, Juho Choi, Youngin Roh, Eunbin Lee, Luigie Villamante, Myung‐Hee Kwon   +5 more
wiley   +1 more source