Results 121 to 130 of about 2,878,819 (307)

Australian professional identity in therapeutic recreation : exploring perspectives from the field

, 2019
The purpose of this case study was to explore the emerging Australian professional identity in the field of Therapeutic Recreation (TR). Within Australia, the field most closely associated with TR is Diversional Therapy (DT).
Truong, Son (R17154), Peel, Nicole (R18401)   +1 more
core  

Therapeutic drug monitoring of monoclonal antibodies in chronic inflammatory diseases: A snapshot of laboratories and applications across Europe [PDF]

The European Cooperation in Science and Technology (COST) action ENOTTA (The European Network on Optimising Treatment with Therapeutic Antibodies in chronic inflammatory diseases) was launched in 2022.
Nielsen, Elisabet, Zaninotto, Martina, Mulleman, Denis, Bogavac-Stanojević, Nataša, Dreesen, Erwin, Skrede, Silje   +5 more
core   +1 more source

Accelerating antibody development: sequence and structure-based models for predicting developability properties via size exclusion chromatography

mAbs
Experimental screening for biopharmaceutical developability properties typically relies on resource-intensive, and time-consuming assays such as size exclusion chromatography (SEC).
A N M Nafiz Abeer, Mehdi Boroumand, Isabelle Sermadiras, Jenna G. Caldwell, Valentin Stanev, Neil Mody, Gilad Kaplan, James Savery, Rebecca Croasdale-Wood, Maryam Pouryahya   +9 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Fcγ-Receptor-Independent Controlled Activation of CD40 Canonical Signaling by Novel Therapeutic Antibodies for Cancer Therapy

The activation of CD40-mediated signaling in antigen-presenting cells is a promising therapeutic strategy to promote immune responses against tumors. Most agonistic anti-CD40 antibodies currently in development require the Fcγ-receptor (FcγR)-mediated ...
Kazandjian, Linda V., Karsten Beckmann, Bluemle, E, Anna Carle, Beckmann, K, Paulmann, Claudia, Prassl, Sandra, Reitinger, C, Paulmann, C, Blümle, Eva, Sandra Prassl, Carle, Anna, Lore, K,, Carle, A, Carmen Reitinger, Jurkschat, Nicole, Beckmann, Karsten, Yan, Xianglei, Xianglei Yan, Kazandjian, LV, Stephan Fischer, Jurkschat, N, Eva Blümle, Nicole Jurkschat, Loré, Karin, Prassl, S, Karin Loré, Falk Nimmerjahn, Nimmerjahn, Falk, Yan, X,, Claudia Paulmann, Linda V. Kazandjian, Reitinger, Carmen, Fischer, Stephan   +33 more
core   +1 more source

Competitive antigen panning for selection of HIV-1 neutralizing human monoclonal antibodies specific for gp41.

, 2009
HIV envelope glycoprotein (Env) is composed of two non-covalently associated subunits: gp120 and gp41. Panning of phage-displayed antibody libraries against gp140 (covalently linked gp120 and the extracellular portion of gp41) has resulted mostly in ...
Zhang, MY, Dimitrov, DS, Zhang, M
core   +1 more source

Implications of immune responses to DENV, JEV, and ZIKV Infections for cross-reactivity and considerations for vaccine evaluation

Virus Research
Dengue virus (DENV), Japanese encephalitis virus (JEV), and Zika virus (ZIKV) are mosquito-borne flaviviruses of global concern, causing illnesses ranging from mild fever to severe neurological or hemorrhagic disease.
Thi Thanh Ngan Nguyen, Mya Myat Ngwe Tun, Thi Bich Hau Vu, Thi Thu Thuy Nguyen, Vu Mai Phuong Hoang, Le Khanh Hang Nguyen, Trong Lan Phan, Duc Anh Dang, Muhareva Raekiansyah, Ryosuke Suzuki, Jean Claude Balingit, Yuki Takamatsu, Corazon C. Buerano, Takeshi Urano, Thi Quynh Mai Le, Futoshi Hasebe, Kouichi Morita   +16 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source