Results 171 to 180 of about 2,878,819 (307)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

European Network on Optimizing Treatment With Therapeutic Antibodies in Chronic Inflammatory Diseases: Overview, Progress and Perspectives. [PDF]

Clin Transl Sci
Tachkov K, Rumano M, Bluett J, Bogavac-Stanojević N, Dreesen E, Itik M, Kararigas G, Kawalec P, Santos M, Skrede S, Petrova G, Mulleman D.   +11 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Innovative use of therapeutic antibodies in lung cancer: the current landscape of ADCs and other antibody-based therapies. [PDF]

Front Oncol
Lee M, Lovly CM.
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

On the trail to therapeutic antibodies

New Biotechnology, 2011
openaire   +2 more sources

A masking clamp for conditional activation of therapeutic antibodies. [PDF]

Front Immunol
Bloch A, Zimmermann JF, Habermann J, Ullrich E, Kolmar H.   +4 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Corrigendum to “Molecular and serological evidence of chikungunya virus among dengue suspected patients in Sri Lanka” [J Infect Public Health 2025;18(5):102709]

Journal of Infection and Public Health
Mya Myat Ngwe Tun, Maurine Mumo Mutua, Shingo Inoue, Yuki Takamatsu, Satoshi Kaneko, Takeshi Urano, Rohitha Muthugala, Lakkumar Fernando, Menaka Hapugoda, YINS Gunawardene, Kouichi Morita   +10 more
doaj   +1 more source

Therapeutic Antibodies in Hematology: Advances in Malignant and Non-Malignant Disorders. [PDF]

Cells
Yasui H, Idogawa M, Ishida T, Imai K.
europepmc   +1 more source