Results 211 to 220 of about 32,878,841 (350)

Comparison of Selected Therapies Within the Step-Up Therapeutic Approach in Canine Chronic Inflammatory Enteropathy. [PDF]

Animals (Basel)
Kunay L, Fialkovičová M, Benková M, Tóthová C, Kořená N, Gomulcová S, Vargová M, Micháľová A, Lukáč B, Bielik B, Staroňová R.   +10 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Psoriasis and Chronic Viral Infections (HIV, HBV, and HCV): Therapeutic Approach and Safety. [PDF]

Medicina (Kaunas)
Almeida-Silva G, Couto-Sousa D, Tribolet-Abreu I, Monteiro F, Ferreira J, Antunes J, Filipe P.   +6 more
europepmc   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Development of a SIN1 Targeting Inhibitor as a Novel Therapeutic Approach for the Treatment of Malignancies. [PDF]

Mol Cancer Ther
Beauchamp EM, Jain A, Clutter M, Nahotko D, Lopez Fajardo E, Vagadia PP, Dunne SF, Mina A, Fischietti M, Oku CV, Blyth GT, Mishra RK, Karras E, Radecki SG, Lantz C, Addepalli S, Modi M, Zou L, Cho BK, Goo YA, Rossoff J, Fish EN, Saleiro D, Schiltz GE, Platanias LC.   +24 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Novel Mechanism of and Therapeutic Approach for Anthracycline-Induced Cardiotoxicity. [PDF]

Cancer Res Commun
Wang Q, Zhang W, Chen J, Stenson KT, Parsai S, Parthasarathy PB, Liu CF, Garrett T, Lin J, Hou A, Shimpi RA, Gu E, Yin M, Shannon L, Johnson S, Willard BB, Rodriguez ER, Androjna C, Moudgil R, Sun Y, Yu JS, Nguyen C, Alban TJ, Chan TA, Prasad SVN, Tang WHW, Lin J, Zhao J.   +27 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Anterior Disc Displacement in a Young Patient With Stage II Osteoarthritis: Diagnostic and Therapeutic Approach. A Case Report. [PDF]

Case Rep Dent
Chamba-León D, Toledo MPS, Sabay-Aldas JD, Suarez KO, Torres WDB.   +4 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source