Results 71 to 80 of about 2,620,997 (289)

The therapeutic effect of traditional Chinese medicine on breast cancer through modulation of the Wnt/β-catenin signaling pathway

Frontiers in Pharmacology
Breast cancer, the most prevalent malignant tumor among women globally, is significantly influenced by the Wnt/β-catenin signaling pathway, which plays a crucial role in its initiation and progression.
Hongkun Li, Jiawei Li, Yifan Zhang, Chengcheng Zhao, Jun Ge, Yujiao Sun, Hui Fu, Yingpeng Li   +7 more
doaj   +1 more source

Know your enemy: Nature and biochemistry of obesity [PDF]

Arhiv za farmaciju
Obesity represents a serious medical condition and has nowadays reached pandemic proportions. Comorbidities associated with obesity are severe, and affect almost all organ systems. Adipose tissue has several important functions: to provide energy storage,
Bjelanović Jasna, Skrobić Ognjan
doaj   +1 more source

Hashimoto’s thyroiditis — a therapeutic or surgical problem? (Literature review)

Mìžnarodnij Endokrinologìčnij Žurnal, 2020
More than a hundred-year history of the study of Hashimoto’s thyroiditis testifies to the urgency of the disease and the theoretical and practical problems not solved yet. From a practical point of view, it is important to choose the therapeutic approach
V.А. Shidlovskyi, А.V. Shidlovskyi, M.I. Sheremet, V.V. Tverdohlib   +3 more
doaj   +1 more source

Is now the time for molecular driven therapy for diffuse large B-cell lymphoma? [PDF]

, 2017
INTRODUCTION: Recent genetic and molecular discoveries regarding alterations in diffuse large B-cell lymphoma (DLBCL) deeply changed the approach to this lymphoproliferative disorder.
Ansuinelli, Michela, DE ANGELIS, Federico, DI ROCCO, Alice, Foa, Roberto, Martelli, Maurizio   +4 more
core   +1 more source

Bayesian data assimilation to support informed decision-making in individualized chemotherapy [PDF]

, 2020
An essential component of therapeutic drug/biomarker monitoring (TDM) is to combine patient data with prior knowledge for model-based predictions of therapy outcomes.
de Wiljes, Jana, Hartung, Niklas, Huisinga, Wilhelm, Kloft, Charlotte, Maier, Corinna   +4 more
core   +2 more sources

Molecular Methods for Rare Hemoglobinopathy Cases: First Brazilian Report of Pediatric Siblings with Hb O‐Arab and Alpha‐Thalassemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hemoglobinopathies are prevalent globally; diagnosis is complex in high genetic admixture populations like Brazil. We report, in two pediatric siblings, the first documented cases in Brazil of heterozygosity for hemoglobin (Hb) O‐Arab with coinheritance of α‐thalassemia (αα/−α4.2; −α3.7/−α4.2), resulting in microcytic and hypochromic anemia ...
Elisângela de Souza Miranda Muynarsk, Amanda Cristina Meneguetti Berti, Bárbara Braga Vieira Marques, Victoria Simões Bernardo, Flaviene Felix Torres, Ingrid Souza Dias, Vanessa da Silveira Ramos de Castro, Gabriela Alves Bernardino, Danilo Grünig Humberto da Silva, Edis Belini‐Júnior   +9 more
wiley   +1 more source

Are Hand Preference and Sexual Orientation Possible Predicting Factors for Finasteride Adverse Effects in Male Androgenic Alopecia? [PDF]

, 2016
Sexual side effects of finasteride seem to be redoubtable, being encountered not only during therapy but also after treatment cessation. Consequently, any possible clinical/paraclinical elements that might predict these adverse effects would be useful in
Berglund, Hu, Irwig, Mondaini, Motofei, Motofei, Motofei, Savic, Savic   +8 more
core   +2 more sources

The Efficacy and Safety of Bevacizumab/Irinotecan/Temozolomide (BIT) for Relapsed/Refractory Neuroblastoma: The UK Children's Cancer and Leukaemia Group Experience

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Patients with high‐risk neuroblastoma who either are refractory to induction chemotherapy or relapse following multi‐modal treatment have a dismal prognosis. Based on data from the BEACON trial, since 2021 the UK national guidelines recommend bevacizumab, irinotecan, and temozolomide (BIT) for patients with relapsed/refractory ...
Thomas J. Jackson, Menna Shamma, Upeka Senanayake, Shaimaa Sahmoud, Kathleen Duffin, Victoria Howard, David King, Ayesha Fathani, Blanche Lumb, Andrei Pobischan, Irum Latif Memon, Monzir Ahmed, Rhian Thomas, Gerard Millen, Yasmeen Alomari, Sucheta Vaidya, Lynley V. Marshall, Sally L. George, Ramya Ramanujachar, Juliet Gray, Paola Angelini   +20 more
wiley   +1 more source

Unraveling the interplay: exploring signaling pathways in pancreatic cancer in the context of pancreatic embryogenesis

Frontiers in Cell and Developmental Biology
Pancreatic cancer continues to be a deadly disease because of its delayed diagnosis and aggressive tumor biology. Oncogenes and risk factors are being reported to influence the signaling pathways involved in pancreatic embryogenesis leading to pancreatic
Sashikanta Swain, Ravi Kant Narayan, Pravash Ranjan Mishra   +2 more
doaj   +1 more source

PHARMACOGENETICS APPROACH TO THERAPEUTICS [PDF]

Clinical and Experimental Pharmacology and Physiology, 2006
1. Pharmacogenetics refers to the study of genetically controlled variations in drug response. Functional variants caused by single nucleotide polymorphisms (SNPs) in genes encoding drug-metabolising enzymes, transporters, ion channels and drug receptors have been known to be associated with interindividual and interethnic variation in drug response ...
Seok Hwee, Koo, Edmund Jon Deoon, Lee
openaire   +2 more sources