Results 41 to 50 of about 6,648,309 (299)
Stem Cell Research & TherapyBackground Under regular culture conditions, mesenchymal stem cells (MSCs) exhibit cytosolic calcium concentration oscillations (Ca2+ oscillations), that change, especially in frequency, after the differentiation of the MSCs.
Leslie A. Vallet +8 more
doaj +1 more source
Targeting the Ubiquitin–Proteasome System and Recent Advances in Cancer Therapy
Cells, 2023 Ubiquitination is a reversible post-translational modification based on the chemical addition of ubiquitin to proteins with regulatory effects on various signaling pathways.
Daniela Spano, Giuliana Catara
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk +10 more
wiley +1 more source
Pharmacological ResearchInhibition of checkpoint kinase 1 (Chk1) has shown to overcome resistance to poly (ADP-ribose) polymerase (PARP) inhibitors and expand the clinical utility of PARP inhibitors in a broad range of human cancers.
Li Tao +5 more
doaj +1 more source
Cholesterol in colorectal cancer: an essential but tumorigenic precursor?
Frontiers in Oncology, 2023 Colorectal cancer (CRC) is one of the most lethal human malignancies, and with the growth of societies and lifestyle changes, the rate of people suffering from it increases yearly. Important factors such as genetics, family history, nutrition, lifestyle,
Xing He +3 more
doaj +1 more source
Therapeutic approaches for transplantation
Current Opinion in Immunology, 2001 Developments in marrow and organ transplantation are mutually interactive. There have been several recent advances in stem cell transplantation: to ensure engraftment using larger doses of stem cells; to substantially reduce the incidence of graft-versus-host disease and marrow rejection using monoclonal antibodies; and to reduce toxicity of the ...
openaire +3 more sources
Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin +17 more
wiley +1 more source
The roles, mechanism, and mobilization strategy of endogenous neural stem cells in brain injury
Frontiers in Aging Neuroscience, 2022 Brain injury poses a heavy disease burden in the world, resulting in chronic deficits. Therapies for brain injuries have been focused on pharmacologic, small molecule, endocrine and cell-based therapies.
Haijing Liu +9 more
doaj +1 more source
No New Therapeutic Approach [PDF]
Deutsches Ärzteblatt international, 2012 In actual fact, achalasia affects the entire esophagus, which is paralyzed (chalasia=relaxation), much too long, and subject to muscular hypertrophy; esophageal folds are therefore lacking, as is correctly shown in the figure accompanying the article. Impedance manometry confirms the fact that the entire esophagus is affected: no spasmolytic drugs will
openaire +2 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID‐19 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality.
Friederike Erdmann +8 more
wiley +1 more source