Results 41 to 50 of about 1,804,866 (311)

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Natural pentacyclic triterpenoid from Pristimerin sensitizes p53-deficient tumor to PARP inhibitor by ubiquitination of Chk1

Pharmacological Research
Inhibition of checkpoint kinase 1 (Chk1) has shown to overcome resistance to poly (ADP-ribose) polymerase (PARP) inhibitors and expand the clinical utility of PARP inhibitors in a broad range of human cancers.
Li Tao, Xiangyu Xia, Shujing Kong, Tingye Wang, Fangtian Fan, Weimin Wang   +5 more
doaj   +1 more source

Cholesterol in colorectal cancer: an essential but tumorigenic precursor?

Frontiers in Oncology, 2023
Colorectal cancer (CRC) is one of the most lethal human malignancies, and with the growth of societies and lifestyle changes, the rate of people suffering from it increases yearly. Important factors such as genetics, family history, nutrition, lifestyle,
Xing He, Huanrong Lan, Ketao Jin, Fanlong Liu   +3 more
doaj   +1 more source

Creating a compendium of third wave therapy strategies : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Psychology at Massey University, Palmerston North, New Zealand [PDF]

, 2018
Third Wave Cognitive Behavioural therapies have received much attention in the practice community recently. However, little has been done to understand how these therapies relate and diverge.
Rous, Michelle Leanne
core  

Positive practices : solution-focused and narrative therapeutic techniques with children with sexually harmful behaviours [PDF]

, 2006
This article explores the use of solution-focused and Narrative Therapeutic approaches with a boy who had sexually harmful behaviours. The paper will highlight the practical challenges of working with someone who is 'problem-saturated' through ...
Berg I. K., Bird J., Burton D., De Shazer S., De Shazer S., Dolan Y., Epston D., Freeman J., Hackett S., Jenkins A., Maletzky B. M., Milner J., Milner J., Milner J., Myers S., Payne M., Print B., Scott D., Steve Myers, Turnell A., Vizard E., Wampole B. E., White M., White M., White M., Winslade J.   +25 more
core   +1 more source

Survival Outcomes and Complications Among Canadian Children With Retinoblastoma: A Population‐Based Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Retinoblastoma (RB) is the most common pediatric ocular cancer, yet population‐based data on survival and risk factors remain limited. This study aimed to describe survival in a large national RB cohort and identify predictors of death and complications.
Samuel Sassine, Ofélie Trudeau‐Ferrin, Caroline Laverdière, Patrick Hamel, Rosanne Superstein, Bénédicte Koukoui, Carole Provost, Paul C. Nathan, Vijay Ramaswamy, Furqan Shaikh, Brenda Gallie, Ashwin Mallipatna, Stephanie Kletke, Helen Dimaras, Hallie Coltin   +14 more
wiley   +1 more source

Calcium oscillations in mesenchymal stem cells, a control on cell cycle progression to influence cell fate towards proliferation or differentiation?

Stem Cell Research & Therapy
Background Under regular culture conditions, mesenchymal stem cells (MSCs) exhibit cytosolic calcium concentration oscillations (Ca2+ oscillations), that change, especially in frequency, after the differentiation of the MSCs.
Leslie A. Vallet, Marina Sánchez-Petidier, Romain Fernandes, Nataliia Naumova, Caterina Merla, Claudia Consales, Giorgia Innamorati, Franck M. André, Lluis M. Mir   +8 more
doaj   +1 more source

The roles, mechanism, and mobilization strategy of endogenous neural stem cells in brain injury

Frontiers in Aging Neuroscience, 2022
Brain injury poses a heavy disease burden in the world, resulting in chronic deficits. Therapies for brain injuries have been focused on pharmacologic, small molecule, endocrine and cell-based therapies.
Haijing Liu, Tao Wei, Tao Wei, Qin Huang, Wei Liu, Yaopeng Yang, Yaju Jin, Danli Wu, Kai Yuan, Pengyue Zhang   +9 more
doaj   +1 more source

Targeting Brutons Tyrosine Kinase in Chronic Lymphocytic Leukemia at the Crossroad between Intrinsic and Extrinsic Pro-survival Signals [PDF]

, 2016
Chemo immunotherapies for chronic lymphocytic leukemia (CLL) showed a positive impact on clinical outcome, but many patients relapsed or become refractory to the available treatments.
Facco, Monica, Frezzato, Federica, Martini, Veronica, Semenzato, Gianpietro, Severin, Filippo, Trentin, Livio, Trimarco, Valentina, Visentin, Andrea   +7 more
core   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács, Zoltán Köllő, Balázs Gellért Karvaly, Mahmoud Obeidat, Rita Nagy, Péter Hegyi, Brigitta Teutsch, Eszter Tuboly, Miklós Garami   +8 more
wiley   +1 more source