Results 21 to 30 of about 1,011,280 (169)
Metabolism-based approaches for autosomal dominant polycystic kidney disease
Frontiers in Molecular Biosciences, 2023 Autosomal Dominant Polycystic Kidney Disease (ADPKD) leads to end stage kidney disease (ESKD) through the development and expansion of multiple cysts throughout the kidney parenchyma.
Ivona Bakaj, Alessandro Pocai
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Syncope: therapeutic approaches.
Journal of the American College of Cardiology, 2009 Syncope is a common clinical problem characterized by transient, spontaneously self-terminating loss of consciousness with complete and prompt recovery; the cause is insufficiency of cerebral oxygen/nutrient supply most often due to a transient fall of systemic arterial pressure to levels below those tolerated by cerebrovascular autoregulation. Careful
Benditt, David G., Nguyen, John T.
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Is Culex modestus a New Usutu virus vector?
Parasites & VectorsUsutu virus is an emerging pathogen transmitted by mosquitoes. Culex modestus mosquitoes are widespread in Europe, but their role in disease transmission is poorly understood.
Alina Soto, Lotte Wauters, Leen Delang
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Alzheimer’s Disease and Impaired Bone Microarchitecture, Regeneration and Potential Genetic Links
Life, 2023 Alzheimer’s Disease (AD) and osteoporosis are both age-related degenerative diseases. Many studies indicate that these two diseases share common pathogenesis mechanisms.
Min Zhang, Shunze Hu, Xuying Sun
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Targeting the Ubiquitin–Proteasome System and Recent Advances in Cancer Therapy
Cells, 2023 Ubiquitination is a reversible post-translational modification based on the chemical addition of ubiquitin to proteins with regulatory effects on various signaling pathways.
Daniela Spano, Giuliana Catara
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Stem Cell Research & TherapyBackground Under regular culture conditions, mesenchymal stem cells (MSCs) exhibit cytosolic calcium concentration oscillations (Ca2+ oscillations), that change, especially in frequency, after the differentiation of the MSCs.
Leslie A. Vallet +8 more
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Cholesterol in colorectal cancer: an essential but tumorigenic precursor?
Frontiers in Oncology, 2023 Colorectal cancer (CRC) is one of the most lethal human malignancies, and with the growth of societies and lifestyle changes, the rate of people suffering from it increases yearly. Important factors such as genetics, family history, nutrition, lifestyle,
Xing He +3 more
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Pharmacological ResearchInhibition of checkpoint kinase 1 (Chk1) has shown to overcome resistance to poly (ADP-ribose) polymerase (PARP) inhibitors and expand the clinical utility of PARP inhibitors in a broad range of human cancers.
Li Tao +5 more
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The roles, mechanism, and mobilization strategy of endogenous neural stem cells in brain injury
Frontiers in Aging Neuroscience, 2022 Brain injury poses a heavy disease burden in the world, resulting in chronic deficits. Therapies for brain injuries have been focused on pharmacologic, small molecule, endocrine and cell-based therapies.
Haijing Liu +9 more
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Therapeutic approaches for transplantation
Current Opinion in Immunology, 2001 Developments in marrow and organ transplantation are mutually interactive. There have been several recent advances in stem cell transplantation: to ensure engraftment using larger doses of stem cells; to substantially reduce the incidence of graft-versus-host disease and marrow rejection using monoclonal antibodies; and to reduce toxicity of the ...
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