Results 21 to 30 of about 1,804,866 (311)

SARS‐CoV‐2 modulation of RIG‐I‐MAVS signaling: Potential mechanisms of impairment on host antiviral immunity and therapeutic approaches

MedComm – Future Medicine, 2022
The coronavirus disease 2019 (COVID‐19) is a global infectious disease aroused by RNA virus severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2).
Mingming Wang, Yue Zhao, Juan Liu, Ting Li   +3 more
doaj   +1 more source

Clinical proteomics for precision medicine: the bladder cancer case [PDF]

, 2017
Precision medicine can improve patient management by guiding therapeutic decision based on molecular characteristics. The concept has been extensively addressed through the application of –omics based approaches.
Frantzi, Maria, Latosinska, Agnieszka, Merseburger, Axel S., Mischak, Harald, Vlahou, Antonia   +4 more
core   +1 more source

CASPASE-3 expression and activity in PBMCs associate with SARS-CoV-2 infection and clinical features

Clinical Immunology Communications
Background: Although vaccines and treatments exist, new SARS-CoV-2 variants continue to emerge. An imbalance between apoptosis and autophagy may contribute to COVID-19 pathogenesis, leading to tissue damage and inflammation. Objective: To investigate the
Vanessa Mylenna Florêncio de Carvalho, Bárbara de Oliveira Silva, Priscilla Stela Santana de Oliveira, Thacianna Barreto da Costa, Michelle Melgarejo da Rosa, Moacyr Jesus Barreto de Melo Rêgo, Michelly Cristiny Pereira, Maira Galdino da Rocha Pitta   +7 more
doaj   +1 more source

Confusion of Therapeutic Approaches [PDF]

Deutsches Ärzteblatt international, 2014
Schlitt et al. in their review article focused on cardiotoxic oncological treatments (1). Adequate management of adverse effects of cardiotoxic treatments ensures optimal results of oncological treatment. In the article by Schlitt et al., an algorithm was proposed for monitoring, prevention, and treatment in the context of cardiotoxicity, including the
Ivanyi, Philipp, Grünwald, Viktor, Steffens, Sandra   +2 more
openaire   +2 more sources

Key Players in HIV-1 Transcriptional Regulation: Targets for a Functional Cure

Viruses, 2020
HIV-1 establishes a life-long infection when proviral DNA integrates into the host genome. The provirus can then either actively transcribe RNA or enter a latent state, without viral production.
Luisa Mori, Susana T. Valente
doaj   +1 more source

A Systematic Review of Therapeutic Approaches Used in Experimental Models of Interstitial Cystitis/Bladder Pain Syndrome

Biomedicines, 2021
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a multifactorial, chronic bladder disorder with limited therapeutic options currently available. The present review provides an extensive overview of therapeutic approaches used in in vitro, ex vivo,
Tadeja Kuret, Dominika Peskar, Andreja Erman, Peter Veranič   +3 more
doaj   +1 more source

Strategizing Drug Therapies in Pulmonary Hypertension for Improved Outcomes

Pharmaceuticals, 2022
Pulmonary hypertension (PH) is characterized by a resting mean pulmonary artery pressure (PAP) of 20 mmHg or more and is a disease of multiple etiologies.
Taylor Beckmann, Patrisha Shelley, Darshan Patel, Mounica Vorla, Dinesh K. Kalra   +4 more
doaj   +1 more source

Targeting the tumor microenvironment in colorectal peritoneal metastases

, 2020
Peritoneal metastasis (PM) occurs in approximately one in four colorectal cancer (CRC) patients. The pathophysiology of colorectal PM remains poorly characterized. Also, the efficacy of current treatment modalities, including surgery and intraperitoneal (
Ceelen, Wim, De Wever, Olivier, Heriot, Alexander G., Narasimhan, Vignesh, Ramsay, Robert G.   +4 more
core   +1 more source

Approaches for modeling magnetic nanoparticle dynamics

, 2014
Magnetic nanoparticles are useful biological probes as well as therapeutic agents. There have been several approaches used to model nanoparticle magnetization dynamics for both Brownian as well as N\'eel rotation. The magnetizations are often of interest
Reeves, Daniel B., Weaver, John B.
core   +1 more source

Therapeutic approaches to gastroesophageal junction adenocarcinomas [PDF]

, 2014
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/108681/1/nyas12532 ...
Agrawal, Aloia, Apisarnthanarax, Ayyappan, Baardwijk, Bang, Barbour, Bettstetter, Blom, Bogush, Bogush, Bruzzi, Brücher, Brücher, Brücher, Brücher, Cerfolio, Chang, Chirieac, Cunningham, Dikken, Dulak, Eto, Farris, Gonzalez, Griffin, Gurland, Hagen, Heijl, Heijl, Illig, Kwee, Lambrecht, Langer, Langer, Loon, Mandard, Mann, Marsman, Medical Research Council Oesophageal Cancer Working Group, Miller, Moertel, Peyre, Peyre, Ronellenfitsch, Rossum, Sarkaria, Schneider, Shapiro, Siewert, Sjoquist, Smit, Stahl, Swisher, Swisher, Takebayashi, Tepper, Therasse, Walsh, Westerterp, Xie   +60 more
core   +1 more source