Results 121 to 130 of about 1,046,320 (355)

Benefits of Therapeutic Drug Monitoring of First Line Antituberculosis Drugs

Acta Medica Martiniana, 2020
Tuberculosis is an airborne infectious disease that remains a huge global health-related issue nowadays. Despite constant approvals of newly developed drugs, the use of first-line antituberculosis medicines seems reasonable in drug-susceptible ...
Prso K, Zidekova N, Dohal M, Porvaznik I, Prso M, Kertys M, Mokry J   +6 more
doaj   +1 more source

Enhancing patient engagement in cancer research: a focus on patient‐centric approaches to scientific discovery

Molecular Oncology, EarlyView.
Patient engagement involves actively including patients in healthcare decisions and research to ensure care and studies align with their needs. This approach improves outcomes, trust, and communication while fostering collaboration between patients and professionals.
Estela Cepeda, Marina Reguero, Vanesa Abón, Marta Puyol   +3 more
wiley   +1 more source

Therapeutic monitoring of psychoactive drugs - antidepressants: A review

Biomedical Papers, 2015
Background: Major depression, is one of the most prevalent mental disorders in Europe and the USA. The dramatic rise in pharmacological antidepressants is mainly due to increase in use of selective serotonin reuptake inhibitors, serotonin and ...
Milan Grundmann, Ivana Kacirova, Romana Urinovska   +2 more
doaj   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Therapeutic drug monitoring in patients with cystic fibrosis and mycobacterial disease [PDF]

, 1999
M. Gilljam, Shaun E. Berning, Charles A. Peloquin, Birgitta Strandvik, L.O. Larsson   +4 more
openalex   +2 more sources

Simultaneous Acoustic Trapping and Imaging of Microbubbles at Clinically Relevant Flow Rates [PDF]

arXiv, 2019
Mechanisms for non-invasive target drug delivery using microbubbles and ultrasound have attracted growing interest. Microbubbles can be loaded with a therapeutic payload and tracked via ultrasound imaging to selectively release their payload at ultrasound-targeted locations.
arxiv  

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Vedolizumab trough level monitoring in inflammatory bowel disease: a state-of-the-art overview

BMC Medicine, 2019
Background Therapeutic drug monitoring involves therapeutic modifications based on the measurement of drug levels and antidrug antibodies. The viability of therapeutic drug monitoring in vedolizumab-treated patients with inflammatory bowel disease ...
Lieven Pouillon, Séverine Vermeire, Peter Bossuyt   +2 more
doaj   +1 more source

Therapeutic Drug Monitoring of Oral Anticancer Drugs: The Dutch Pharmacology Oncology Group-Therapeutic Drug Monitoring Protocol for a Prospective Study.

Therapeutic Drug Monitoring, 2019
BACKGROUND Oral anticancer drugs show a high interpatient variability in pharmacokinetics (PK), leading to large differences in drug exposure. For many of these drugs, exposure has been linked to efficacy and toxicity. Despite this knowledge, these drugs
S. Groenland, Ruben A. G. van Eerden, R. Verheijen, S. Koolen, D. Moes, I. Desar, A. Reyners, H. Gelderblom, N. V. van Erp, R. Mathijssen, A. Huitema, N. Steeghs   +11 more
semanticscholar   +1 more source

Concepts for the Rational Selection of Assays to Be Used in Monitoring Therapeutic Drugs [PDF]

, 1975
Mario Werner, Earl W. Sutherland, Fred P. Abramson   +2 more
openalex   +1 more source