Results 101 to 110 of about 6,272,911 (310)

Therapeutic drug monitoring of voriconazole

, 2015
Invasive fungal diseases are associated with significant morbidity and mortality, especially in immunocompromised patients. Voriconazole is a first-line treatment for invasive aspergillosis, and an effective agent for candidiasis, fusariosis and ...
VIALE, PIERLUIGI, LEWIS, RUSSEL EDWARD
core  

Monitoring of thiopurine metabolites in patients with inflammatory bowel disease-what is actually measured?

, 2009
Azathioprine and 6-mercaptopurine are often used in the treatment of patients with inflammatory bowel disease (IBD). They are prodrugs and undergo a complex metabolism to active and inactive metabolites.
Peterson, Curt,, Vikingsson, Svante,, Carlsson, Björn,, Almer, Sven H C,   +3 more
core   +1 more source

Therapeutic Drug Monitoring [PDF]

Deutsches Ärzteblatt international, 2019
Ramona, Dolscheid-Pommerich, Birgit, Stoffel-Wagner   +1 more
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Determination of Unbound Antiretroviral Drug Concentrations by a Modified Ultrafiltration Method Reveals High Variability in the Free Fraction

, 2008
Total plasma concentrations are used for therapeutic drug monitoring of antiretroviral drugs, whereas antiviral activity is expected to depend on unbound concentrations.
Thierry Buclin, Béguin, A., Decosterd, L.A., Fayet, A., Begona Martinez de Tejada, Laurent A Decosterd, Amalio Telenti, Eap, C.B., Biollaz, J., Alexandre Béguin, Cavassini, M., Jérôme Biollaz, Telenti, A., Sara Colombo, Gerber, S., Buclin, T., Stefan Gerber, Chin B Eap, Colombo, S., Aurélie Fayet, Matthias Cavassini, de Tejada, B.M.   +21 more
core   +1 more source

Inter- and intraindividual pharmacokinetic variations of mirtazapine and its N-demethyl metabolite in patients treated for major depressive disorder - A 6-month therapeutic drug monitoring study

, 2005
Mirtazapine pharmacokinctic (PK) data from patients on long-term treatment for major depression have never been investigated. For this reason, in a large naturalistic outpatient study (prospective, multicenter, open-labeled, and noncomparative) conducted
Reis, Margareta,, Sitsen, A, Ahlner, J, Bengtsson, F, Prochazka, J, Lund University.   +5 more
core   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Therapeutic drug monitoring of erlotinib in non-small cell lung carcinoma: A case study

We describe a clinical case of an 84-year-old man diagnosed with non-small cell lung carcinoma (NSCLC) and epidermal growth factor receptor (EGFR) mutation, who was treated with erlotinib, with doses adjusted by therapeutic drug monitoring (TDM).
Sureda, Manuel, Catalán Latorre, Ana, Brugarolas-Masllorens Antonio, Escudero-Ortiz, Vanesa   +3 more
core   +1 more source

AIF1 Gene RS2269475:C>T Polymorphism is Associated With Rheumatoid Arthritis Development but not With Disease Activity

The Turkish Journal of Gastroenterology, 2015
Objectives: This study aims to examine whether the allograft inflammatory factor-1 (AIF1) gene rs2269475:C>T polymorphism is associated with rheumatoid arthritis (RA) susceptibility, and whether this polymorphism influences disease activity in patients ...
Andrzej PAWLIK, Violetta DZIEDZIEJKO, Mateusz KURZAWSKI, Krzysztof SAFRANOW   +3 more
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