Results 91 to 100 of about 6,272,911 (310)

Therapeutic Drug Monitoring of Targeted Anticancer Protein Kinase Inhibitors in Routine Clinical Use: A Critical Review

, 2020
Background: Therapeutic response to oral targeted anticancer protein kinase inhibitors (PKIs) varies widely between patients, with insufficient efficacy of some of them and unacceptable adverse reactions of others.
Decosterd, Laurent, Thierry Buclin, Decosterd, L.A., Nicolas Widmer, Widmer, N., Schneider Voirol, Marie Paule, Guidi, M., Cardoso, Evelina, Cardoso, E., Benoît Blanchet, Marie Paule Schneider, Schneider, M.P., Chantal Csajka, Guidi, Monia, Csajka, C., Evelina Cardoso, Csajka, Chantal, Buclin, T., Widmer, Nicolas, Blanchet, B., Laurent A. Decosterd, Blanchet, Benoît, Monia Guidi, Buclin, Thierry, Decosterd LA, Schneider MP, Csajka C, Widmer N, Blanchet B, Buclin T, Guidi M, Cardoso E   +31 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Rapporto tecnico-professionale della rendicontazione economica referente amministrativo dell'IREA del Progetto NANODEM "NANO photonic DEvice for Multiple therapeutic drug monitoring" nell'ambito del Settimo Programma Quadro della Commissione Europea Grant Agreement Number 318372

, 2020
Procedura di rendicontazione economica del progetto NANODEM "NANO photonic DEvice for Multiple therapeutic drug monitoring" nell'ambito del Settimo Programma Quadro della Commissione ...
Francesca Di Matteo
core  

Haploidentical Hematopoietic Cell Transplantation for Infants With X‐Linked Severe Combined Immunodeficiency Using Post‐Transplant Cyclophosphamide

Pediatric Blood &Cancer, EarlyView.
Shuhei Takahashi, Akito Kawachi, Dan Tomomasa, Eri Watanabe, Yuji Fujita, Yuya Sato, Masahiro Sekiguchi, Kentaro Watanabe, Moe Hidaka, Akihiro Hoshino, Takahiro Kamiya, Masatoshi Takagi, Hirokazu Kanegane, Motohiro Kato   +13 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Serum Concentrations of Antidepressant Drugs in a Naturalistic Setting : Compilation Based on a Large Therapeutic Drug Monitoring Database

, 2009
A compilation of therapeutic drug monitoring data for 15 antidepressant drugs in a naturalistic routine clinical setting is presented. A substantial number of serum concentrations, at different daily doses, are outlined, and the intraindividual and ...
Reis, Margareta,, Spigset, Olav,, Ahlner, Johan,, Aamo, Trond,   +3 more
core  

Simultaneous profiling of classic and 11-oxygenated androgens via a novel derivatization method coupled with HPLC-MS/MS: A game-changer for endocrine disorders

Talanta Open
The accumulation of classic or 11-oxygenated androgens is a hallmark of polycystic ovary syndrome (PCOS). Traditional electrochemiluminescence immunoassays (ECLIA) are limited in their ability to measure a broad spectrum of androgens and may suffer from ...
Xianhua Zhang, Huiyu Xu, Yue Sun, Xin Xiong, Lingling Liu, Li Yang, Libo Zhao, Xiaona Li, Rong Li, Rongsheng Zhao   +9 more
doaj   +1 more source

Effects of fluvoxamine on duloxetine plasma concentrations: A case series

Psychiatry and Clinical Psychopharmacology, 2021
Objective: Duloxetine is metabolized in liver by CYP1A2 enzyme. Concomitant Concomitant use of fluvoxamine, which is an inhibitor of CYP 1A2 enzyme with duloxetine may increase bioavailability of duloxetine from 42,8% to 81.9%, and plasma levels by 141%-
Esra Sağlam, Birim Sungu Danışmant, Gül Eryılmaz, Fadime Canbolat, Kaşif Nevzat Tarhan   +4 more
doaj  

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source