Results 111 to 120 of about 3,107,552 (340)

Algebraic and Topological Indices of Molecular Pathway Networks in Human Cancers [PDF]

, 2014
Protein-protein interaction networks associated with diseases have gained prominence as an area of research. We investigate algebraic and topological indices for protein-protein interaction networks of 11 human cancers derived from the Kyoto Encyclopedia
Hinow, Peter, Rietman, Edward A., Tuszynski, Jack A.   +2 more
core  

Prediction of Emerging Technologies Based on Analysis of the U.S. Patent Citation Network

, 2013
The network of patents connected by citations is an evolving graph, which provides a representation of the innovation process. A patent citing another implies that the cited patent reflects a piece of previously existing knowledge that the citing patent ...
A. Hargadon, A. Jaffe, A. Pyka, A. Sood, A. Usher, A. Verbeek, A. Vespignani, B. Milman, C. Chen, C. Sternitzke, C. Weng, D. Harhoff, E. Duguet, E. Garfield, E. Garfield, F. Murray, F. Narin, G. McMillanm, G. Palla, H. Moed, H. Small, H. Small, J. Alcacer, J. Hagedoorn, J. Lanjouw, J. Podolny, J. Podolny, J. Schumpeter, J. Ward, Jan Tobochnik, K. Debackere, K. Lai, K. OuYang, K. Strandburg, K. Strandburg, Katherine Strandburg, Kinga Makovi, L. Fleming, L. Fleming, L. Fleming, L. Leydesdorff, László Zalányi, M. Girvan, M. Meyer, M. Meyer, M. Mogee, M. Mogee, M. Mogee, M. Newman, M. Newman, M. Wallace, M. Weitzman, N. Shibata, N. Shibata, N. Shibata, O. Sorenson, P. Almeida, P. Pons, P. Saviotti, P. Saviotti, P. Saviotti, P. Érdi, P.C. Lee, Péter Volf, Péter Érdi, R. Fontana, R. Henderson, R. Kostoff, R. Kostoff, R. Kostoff, R. Tijssen, S. Chang, Y. Kajikawa, Y. Kajikawa, Z. Huang, Z. Huang, Zoltán Somogyvári   +76 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

A randomized, cross-over trial of metoprolol succinate formulations to evaluate PK and PD end points for therapeutic equivalence. [PDF]

Clin Transl Sci, 2022
Mosley SA, Kim S, El Rouby N, Lingineni K, Esteban VV, Gong Y, Chen Y, Estores D, Feng K, Kim H, Kinjo M, Langaee T, Li Z, Schmidt SOF, Johnson JA, Frye RF, Fang LL, Zhao L, Binkley PF, Schmidt S, Cavallari LH.   +20 more
europepmc   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

A comparative study of the therapeutic equivalence (efficacy, safety, and tolerability) and pharmacokinetics of brand-name and generic rivaroxaban in patients with non-valvular atrial fibrillation

Рациональная фармакотерапия в кардиологии
Aim. To study the therapeutic equivalence (efficacy, safety, and tolerability) and pharmacokinetics of the brand-name and generic rivaroxaban 20 mg in patients with non-valvular atrial fibrillation and a high risk of thromboembolic complications.Material
E. A. Pravkina, K. G. Pereverzeva, S. S. Yakushin, P. Yu. Mylnikov, E. G. Chekanova, T. S. Degtiareva, A. V. Shchulkin   +6 more
doaj   +1 more source

A COMPARATIVE STUDY OF EFFICACY AND TOLERABILITY OF GENERIC AND ORIGINAL LOW-DOSE BISOPROLOL/HYDROCHLOROTHIAZIDE COMBINATION IN PATIENTS WITH ARTERIAL HYPERTENSION OF 1-2 DEGREES. RESULTS OF CLINICAL RANDOMIZED CROSSOVER STUDY

Рациональная фармакотерапия в кардиологии, 2015
Aim. To study the clinical equivalence of the two low-dose combined drugs on the base of generic and original bisoprolol and hydrochlorothiazide (HCTZ): BISANGIL® (Ozon, Russia) and LODOZ® (NYCOMED, Merck KGaA, Germany) in patients with arterial ...
S. Yu. Martsevich, S. N. Tolpygina, A. V. Zakharova, V. P. Voronina, O. V. Lerman, Yu. V. Lukina, N. A. Dmitrieva, N. V. Kiseleva   +7 more
doaj   +1 more source

The Scientist-Practitioner in a Counselling Psychology Setting [PDF]

, 2006
The human psyche is influenced by an extraordinary complexity of experiences. Many would therefore maintain that we can never completely understand another human being.
Bury, D., Strauss, S. M.
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Pharmacodynamic testing and new validated HPLC method to assess the interchangeability between multi-source orlistat capsules

Drug Design, Development and Therapy, 2017
Abdel Naser Zaid,1 Nihal Zohud,1 Bushra E’layan,1 Tasneem Aburadi,1 Nidal Jaradat,1 Iyad Ali,2 Fatima Hussein,1 Mashhour Ghanem,3 Aiman Qaddomi,3 Yara Abu Zaaror4 1Department of Pharmacy, 2Department of Biomedical Sciences, Faculty of Medicine and
Zaid AN, Zohud N, E'layan B, Aburadi T, Jaradat N, Ali I, Hussein F, Ghanem M, Qaddomi A, Abu Zaaror Y   +9 more
doaj