Results 41 to 50 of about 28,368 (156)

A comparative study of the therapeutic equivalence (efficacy, safety, and tolerability) and pharmacokinetics of brand-name and generic rivaroxaban in patients with non-valvular atrial fibrillation

Рациональная фармакотерапия в кардиологии
Aim. To study the therapeutic equivalence (efficacy, safety, and tolerability) and pharmacokinetics of the brand-name and generic rivaroxaban 20 mg in patients with non-valvular atrial fibrillation and a high risk of thromboembolic complications.Material
E. A. Pravkina, K. G. Pereverzeva, S. S. Yakushin, P. Yu. Mylnikov, E. G. Chekanova, T. S. Degtiareva, A. V. Shchulkin   +6 more
doaj   +1 more source

A COMPARATIVE STUDY OF EFFICACY AND TOLERABILITY OF GENERIC AND ORIGINAL LOW-DOSE BISOPROLOL/HYDROCHLOROTHIAZIDE COMBINATION IN PATIENTS WITH ARTERIAL HYPERTENSION OF 1-2 DEGREES. RESULTS OF CLINICAL RANDOMIZED CROSSOVER STUDY

Рациональная фармакотерапия в кардиологии, 2015
Aim. To study the clinical equivalence of the two low-dose combined drugs on the base of generic and original bisoprolol and hydrochlorothiazide (HCTZ): BISANGIL® (Ozon, Russia) and LODOZ® (NYCOMED, Merck KGaA, Germany) in patients with arterial ...
S. Yu. Martsevich, S. N. Tolpygina, A. V. Zakharova, V. P. Voronina, O. V. Lerman, Yu. V. Lukina, N. A. Dmitrieva, N. V. Kiseleva   +7 more
doaj   +1 more source

Sample Size Calculation for the Therapeutic Equivalence Problem

Communications in Statistics - Simulation and Computation, 2006
A method is proposed for the sample size calculation in the case of therapeutic equivalence of two pharmaceuticals, when the decision is based on post-treatment differences and the post-treatment values are dependent on the pretreatment ones. When the correlation coefficient is large (over 0.7), it is shown that sample size calculation (and the ...
Bassiakos, Y.C., Katerelos, P.C.
openaire   +2 more sources

A randomized, cross-over trial of metoprolol succinate formulations to evaluate PK and PD end points for therapeutic equivalence. [PDF]

Clin Transl Sci, 2022
Mosley SA, Kim S, El Rouby N, Lingineni K, Esteban VV, Gong Y, Chen Y, Estores D, Feng K, Kim H, Kinjo M, Langaee T, Li Z, Schmidt SOF, Johnson JA, Frye RF, Fang LL, Zhao L, Binkley PF, Schmidt S, Cavallari LH.   +20 more
europepmc   +1 more source

Examining therapeutic equivalence between branded and generic warfarin in Brazil: The WARFA crossover randomized controlled trial. [PDF]

PLoS One, 2021
Gomes Freitas C, Walsh M, Coutinho EL, Vincenzo de Paola AA, Atallah ÁN.   +4 more
europepmc   +1 more source

Therapeutic Equivalence of a New Preparation of Liquid Levothyroxine with Tablets in Patients with Overt Primary Hypothyroidism. [PDF]

Eur Thyroid J, 2021
Markantes GK, Dimitropoulos K, Mamali I, Tseti I, Sakellaropoulos G, Markou KB, Michalaki MA.   +6 more
europepmc   +1 more source

Therapeutic equivalence of ivermectin 1% and two novel formulations combined of ivermectin 1% + fluazuron 12.5% for the control of Rhipicephalus (Boophilus) microplus in beef cattle from Uruguay. [PDF]

Open Vet J, 2021
Robaina D, Alvariza S, Suárez G.
europepmc   +1 more source

Discussion of EMA Draft Guideline on Quality and Equivalence of Topical Products Based on Comparison of Approved Mometasone Furoate Drugs

Dermatology and Therapy
Introduction Today, the approval for a generic topical product includes the presentation of therapeutic equivalence to the originator based on clinical trials.
Adina Eichner, Yahya Mrestani, Martin Hukauf, Johannes Wohlrab   +3 more
doaj   +1 more source

Pharmacodynamic testing and new validated HPLC method to assess the interchangeability between multi-source orlistat capsules

Drug Design, Development and Therapy, 2017
Abdel Naser Zaid,1 Nihal Zohud,1 Bushra E’layan,1 Tasneem Aburadi,1 Nidal Jaradat,1 Iyad Ali,2 Fatima Hussein,1 Mashhour Ghanem,3 Aiman Qaddomi,3 Yara Abu Zaaror4 1Department of Pharmacy, 2Department of Biomedical Sciences, Faculty of Medicine and
Zaid AN, Zohud N, E'layan B, Aburadi T, Jaradat N, Ali I, Hussein F, Ghanem M, Qaddomi A, Abu Zaaror Y   +9 more
doaj  

Therapeutic Equivalence of Biosimilar and Reference Biologic Drugs in Rheumatoid Arthritis: A Systematic Review and Meta-analysis.

JAMA Netw Open, 2023
Ascef BO, Almeida MO, Medeiros-Ribeiro AC, Oliveira de Andrade DC, Oliveira Junior HA, de Soárez PC.   +5 more
europepmc   +1 more source