Results 51 to 60 of about 51,423 (237)

Intraoperative Collection of Ascitic Fluid With Intra‐ or Postoperative Reinfusion in Ovarian Cancer: Safety and Feasibility of a Roller Pumping Method

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Patients with ovarian cancer often present with massive ascites, leading to significant protein loss during surgical procedures. Although cell‐free concentrated ascites reinfusion therapy (CART) is used in palliative settings to mitigate protein loss, its application in intraoperative settings remains unexplored.
Yutaka Yoneoka, Tsukuru Amano, Akimasa Takahashi, Mari Deguchi, Hiroyuki Yamanaka, Yuji Tanaka, Shunichiro Tsuji, Takashi Murakami   +7 more
wiley   +1 more source

Original drugs and generics: are there any differences from the clinician’s point of view?

Рациональная фармакотерапия в кардиологии
The article defines the original drug (OD) and examines the history of the appearance of generic drugs (GD), as well as the evolution of views to prove their bioequivalence to OD.
S. Yu. Martsevich, N. P. Kutishenko, O. M. Drapkina   +2 more
doaj   +1 more source

Therapeutic equivalence of inhaled salbutamol [PDF]

Thorax, 2000
The meta-analysis by Hughes et al was hindered by difficulties in comparing trials that were often flawed and of varied design.1 The authors correctly pointed out that, in most of the studies, the use of equivalence as the null hypothesis was invalid. In addition, all but two of the studies looked at the bronchodilator effects in the presence of basal ...
openaire   +1 more source

Bioavailability, Antipsoriatic Efficacy and Tolerability of a New Light Cream with Mometasone Furoate 0.1% [PDF]

, 2012
Mometasone furoate, a potent glucocorticoid (class III) with a favorable benefit/risk ratio, has emerged as a standard medication for the treatment of inflammatory skin disorders.
Ayres JW, Borelli C, Brown PH, C. Schöllmann, C. Willers, Cornell RC, Dumas KJ, Faergemann J, H.C. Korting, Haigh JM, Hoffmann K, Hughes J, Katz HI, Kerscher MJ, Kirkland R, Koivukangas V, Korting HC, Korting HC, Korting HC, Korting HC, Kulhalli P, Medansky RS, Olsen EA, Poulsen J, Prakash A, Proksch E, Sequira J, Surber C, W. Wigger-Alberti, Wiedersberg S, Wilkinson SM   +30 more
core   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

The problem of choosing between the original and of generic drugs in patients with overweight and obesity

Ожирение и метаболизм, 2013
This review article discusses the similarities and differences in the research, production and use in clinical practice, original and generic drugs. Reproduced drugs (generics) present on the Russian pharmaceutical market that have the bioequivalence ...

doaj   +1 more source

Psychological, social and welfare interventions for psychological health and well-being of torture survivors [PDF]

, 2011
This is the protocol for a review and there is no abstract. The objectives are as follows: Primary objective 1. To assess beneficial and adverse effects of psychological, social and welfare interventions versus no treatment for the reduction of ...
Basoglu, Bisson, Boyle, Boyle, Bracken, Bracken, Elsass, Gurr, Higgins, Higgins, Hollifield, Jacobs, Jaranson, Jaranson, Johnson, Johnson, Kutchins, Lund, Mahtani, McIvor, Montgomery, Moreno, Newlands, Nicholl, Norredam, Nuesch, Ommeren, Patel, Patel, Patel, Pilgrim, Preston, Quiroga, Summerfield, Thakker, Westermeyer, Yates,  Higgins   +37 more
core   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Non-biological Complex Drugs (NBCDs): Complex Pharmaceuticals in Need of Individual Robust Clinical Assessment Before Any Therapeutic Equivalence Decision

Frontiers in Medicine, 2020
Non-Biological Complex Drugs (NBCDs) are complex non-biological drugs comprised of large high molecular weight molecules and, often, nanoparticular structures (including liposomes and block-copolymer micelles). In the case of NBCDs, the entire complex is
Rogério Sá Gaspar, Rogério Sá Gaspar, Beatriz Silva-Lima, Beatriz Silva-Lima, Fernando Magro, Fernando Magro, Fernando Magro, Fernando Magro, Armando Alcobia, Armando Alcobia, Fernando Leal da Costa, Fernando Leal da Costa, José Feio, José Feio   +13 more
doaj   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source