Results 231 to 240 of about 1,519,681 (281)

Development of the Gutti Score: A Universal Clinical Assessment Framework for Patients Receiving Gabapentinoids, Opioids, Benzodiazepines, and Other Central Nervous System Depressants. [PDF]

Cureus
Gutti S, Riyadh S.
europepmc   +1 more source

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Therapeutic equivalency of procainamide—A correction

American Journal of Cardiology, 1991
Blair P. Grubb
exaly   +2 more sources

Understanding Therapeutic Equivalence in Epilepsy

CNS Spectrums, 2010
ABSTRACTThe issues surrounding generic drug substitution in patients with epilepsy are complex.The substitution of one formulation of an antiepileptic drug (AED) for another is controversial. Well-reasoned and defensible cases can be made both for and against such substitution.
Raman, Sankar, Tracy A, Glauser
openaire   +2 more sources

The therapeutic equivalence of complex drugs

Regulatory Toxicology and Pharmacology, 2011
When the patent of a small molecule drug expires generics may be introduced. They are considered therapeutically equivalent once pharmaceutical equivalence (i.e. identical active substances) and bioequivalence (i.e. comparable pharmacokinetics) have been established in a cross-over volunteer study.
Schellekens, Huub, Klinger, Ety, Mühlebach, Stefan, Brin, Jean-Francois, Storm, Gert, Crommelin, Daan J. A.   +5 more
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On the Definition of Therapeutic Equivalence

Drug Information Journal, 2000
What do we mean by therapeutic equivalence and how do we prove that two drugs are therapeutically equivalent? We suggest that therapeutic equivalence should be defined and demonstrated using predefined limits on the dose scale rather than on the effect scale.
Anders Källén, Per Larsson
openaire   +1 more source

GENERIC DRUGS AND THERAPEUTIC EQUIVALENCE

JAMA: The Journal of the American Medical Association, 1968
In recent years, there has developed the belief that nonproprietary or generic drugs are much cheaper than, and as effective as, trade-named items. This belief has led to a widespread demand that prescribing and use of generic drugs be encouraged. Studies conducted by impartial groups such as the Medical Letter on Drugs and Therapeutics have applied ...
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On Therapeutic Equivalency and the Antisubstitution Laws

JAMA: The Journal of the American Medical Association, 1973
The comparative bioavailability of a drug in similarly formulated preparations is becoming a subject of considerable interest and importance to the physician. Drugs usually are not administered as pure compounds but are combined with materials such as binders, excipients, lubricants, preservatives, or other substances generally considered to be ...
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Therapeutic equivalence: fallacies and falsification

Statistics in Medicine, 2003
AbstractThe number of studies designed specifically to demonstrate therapeutic equivalence or alternatively non‐inferiority of pharmaceutical treatments has increased dramatically in recent years, during which time awareness of the methodological issues has increased. Regulatory authorities have been quick to recognize the need for specific support and
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Therapeutic equivalency of two lidocaine preparations

American Journal of Health-System Pharmacy, 1976
Twenty-five volunteers were studied as to the onset and duration of action of two commercial brands of lidocaine. One and two percent concentrations of the preparations were tested intradermally using a double-blind, cross-over protocol. Both needle-drop and electrical stimulation techniques were employed as the source of pain stimulus. Five additional
J E, Stambaugh, I W, Wainer, D M, Hemphill   +2 more
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