Results 51 to 60 of about 5,258 (286)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Comparison of the Effects and Safety of Planned Limited-Time Withdrawal Versus Continuous Maintenance of Interleukin Inhibitors in Patients with Psoriasis: A Systematic Review and Network Meta-Analysis

Dermatology and Therapy
Introduction Recent trials with withdrawal arms in patients with psoriasis have highlighted the need for updated clinical guidance. The aim of this investigation was to compare the effects and safety of planned limited-time withdrawal versus continuous ...
Rodrigo R. de Sena, Kleyton de C Mesquita, Letícia F. Barroso, Paola B. E. Canabrava, Fernando Zanghelini, Ciro M. Gomes   +5 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Adaptation of the revised helping alliance questionnaire patient version (HAQ-II-P) for the population of cordobans [PDF]

, 2013
La Psicología Basada en la Evidencia resultaría incompleta si no indagara el rol de la relación terapéutica. No obstante la ausencia de instrumentos adaptados obstaculiza el desarrollo de estudios empíricos en el contexto local.
Conn, Hanne, Moretti, Luciana Sofía, Medrano, Leonardo   +2 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

New Frontiers in Management of Early and Advanced Rectal Cancer

, 2022
It is important to understand advances in treatment options for rectal cancer. We attempt to highlight advances in rectal cancer treatment in the form of a systematic review.
Sang W. Lee, Jordan R. Wlodarczyk
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Equivalency of nuclear transfer-derived embryonic stem cells to those derived from fertilized mouse blastocysts.

, 2006
Therapeutic cloning, whereby nuclear transfer (NT) is used to generate embryonic stem cells (ESCs) from blastocysts, has been demonstrated successfully in mice and cattle.
459239, Nishikawa, Shinichi, Senda, Sho, 若山 照彦, Wakayama, Sayaka, Miyake, Masashi, 459241, 459240, 459243, 459242, 安倍 真澄, 459245, Tanaka, Satoshi, 459244, Suzuki, Masako, 459247, Okada, Mitsuhiro, 459246, 459227, 459226, 459229, 459228, Ohta, Hiroshi, L, Jakt Martin, Mizutani, Eiji, Wakayama, Teruhiko, Shiota, Kunio, Hikichi, Takafusa, 西川 伸一, Sakaide, Yuko, Araki, Ryoko, Abe, Masumi, 荒木 良子, 459230, Kishigami, Satoshi, 459232, 459231, 459234, 459233, Van, Thuan Nguyen, 459236, 459235, 459238, 459237   +43 more
core   +1 more source

The pyruvate generator is a common phenomenon in mitochondria from different rat and mouse brain regions

FEBS Letters, EarlyView.
The pyruvate generator, which causes activation of respiration by extra‐mitochondrial Ca2+, is also present and functional in rat brainstem mitochondria, as it is in other brain regions. This finding is confirmed by experiments with a fully reconstituted malate–aspartate shuttle (MAS).
Grazyna Debska‐Vielhaber, Niki Karavasili, Matthias Kunz, Zemfira Gizatullina, Timur Gainutdinov, Stefan Vielhaber, Wolfram S. Kunz, Frank N. Gellerich   +7 more
wiley   +1 more source