Results 61 to 70 of about 5,258 (286)

Genomic and functional comparison of mesenchymal stromal cells prepared using two isolation methods

, 2015
Background aims: Mesenchymal stromal cells (MSCs) have been applied to patients in cell therapy for various diseases. Recently, we introduced a novel MSC separation filter device which could yield approximately 2.5-fold more MSCs from bone marrow in a ...
Otsuru, Satoru, DOMINICI, Massimo, Guess, Adam J., Olson, Timothy S., Hofmann, Ted J., Raman, Pichai, Horwitz, Edwin M.   +6 more
core   +1 more source

Development of a novel labour monitoring tool: Improving labour care quality in the Indian setting

Journal of Family Medicine and Primary Care
Introduction: Efficient care by labour monitoring tools manages labour, identifies the abnormalities and avoids the fatalities. Various studies are being undertaken by the researchers to understand the limited use of these therapeutic tools.
Shivani Sharma, Saroj Parwez, Kiran Batra   +2 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Retrospective evaluation of the dose equivalence of Botox and Dysport in the management of blepharospasm and hemifacial spasm: a novel paradigm for a never ending story

, 2011
Botox(®) and Dysport(®) are the preparations of botulinum neurotoxin most widely used for therapeutic purposes. Several studies have addressed the topic of the equivalency ratio (D/B ratio) to be used in clinical practice and whether a reliable value ...
Francesca De Nigris, Fasano, Alfonso, Bentivoglio, Anna Rita, Anna Rita Bentivoglio, Tàmara Ialongo, Alfonso Fasano, Francesco Bove   +6 more
core   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Therapeutic equivalence of inhaled salbutamol [PDF]

Thorax, 2000
The meta-analysis by Hughes et al was hindered by difficulties in comparing trials that were often flawed and of varied design.1 The authors correctly pointed out that, in most of the studies, the use of equivalence as the null hypothesis was invalid. In addition, all but two of the studies looked at the bronchodilator effects in the presence of basal ...
openaire   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Structural and Physicochemical Characteristics of One-Step PAMAM Dendrimeric Nanoparticles

, 2022
International audienceThe recently developed One-Step Poly(amidoamine) (OS-PAMAM) dendrimers stand out for their characteristics as the high drug-load capacity and cell-delivery improvement of therapeutic agents. The OS-PAMAM dendrimers have proven to be
Herbert-Pucheta, José, Enrique, Vallejo-Castillo, Luis, Ramón-Gallegos, Eva, Andrés Torres-Pérez, Sergio, Zepeda-Vallejo, Luis, Gerardo, Mayra Pérez-Tapia, Sonia, Dague, Etienne, Severac, Childérick, Vázquez-Leyva, Said   +8 more
core   +1 more source

Exploring the association between pharmacy curricular tracks and students’ attitudes toward generic medicines: insights from a comparative study in Egypt

Frontiers in Pharmacology
BackgroundUse of generic medicines enhances drug affordability and accessibility. The aim if this study was to assess the association between pharmacy educational programs and final-year pharmacy students’ perceptions and confidence in generic medicines ...
Eman. S. Sawan, Mahmoud Mostafa, Yara T. Sayed, Ammena Y. Binsaleh, Mahmoud A. Mohamed, Raghda R. S. Hussein   +5 more
doaj   +1 more source