In a cohort of 42 women who used hybrid closed loop systems in pregnancy, time in the pregnancy target range (3.5–7.8 mmol/L) increased from 57% (44.5%–65%) at first visit to 73% (65%–82%) at 34 weeks (p < 0.001). Frequency of severe hypoglycaemia was low and there were no episodes of diabetic ketoacidosis.
Dimitra Stathi +4 more
wiley +1 more source
Effects of therapeutic hypothermia on brain function in a refractory cardiac arrest model treated with extracorporeal cardiopulmonary resuscitation. [PDF]
Moreau A +8 more
europepmc +1 more source
Conservation of Neuron‐Astrocyte Correlated Activity in Developing Sensory Pathways
Astrocytes and neurons in the superior colliculus exhibit spatiotemporal correlated activity before eye opening. Each neuronal wave is followed by a calcium wave in astrocytes. Spillover of glutamate activates mGluR5 and mGluR3 in astrocytes. ABSTRACT Neurons in developing sensory organs exhibit prolonged burst firing before the onset of sensory ...
Vered Kellner +8 more
wiley +1 more source
Prominent astrocytic GLAST pathology occurs in newborn human and piglet hypoxic-ischemic encephalopathy: modeling relationships among laminar neuropathology, seizures, and therapeutic hypothermia. [PDF]
Park D, O'Brien CE, Lee JK, Martin LJ.
europepmc +1 more source
Population Pharmacokinetics and Dosing Simulations of Pentobarbital in the Pediatric Population
Abstract Pentobarbital is a barbiturate with sedative and anticonvulsant properties, occasionally used in pediatric patients for preoperative sedation, deep sedation during mechanical ventilation, and seizure control. Despite its long‐standing clinical use, age‐appropriate dosing remains challenging due to variability across studies and limited ...
Victoria Etges Helfer +12 more
wiley +1 more source
Efficacy of Intravascular Therapeutic Hypothermia for Moderate to Severe Hypoxic-Ischemic Encephalopathy. [PDF]
Kurimoto T +10 more
europepmc +1 more source
Through a 2 × 2 between‐subjects experimental design varying winter weather forecasts and health impact information, we investigated the influence of efficacy and health locus of control (HLOC) on risk perception and protective behavioral intention.
Zoey Rosen, Will Livingston
wiley +1 more source
Respiratory management in neonates with hypoxic-ischemic encephalopathy during therapeutic hypothermia: a binational analysis of current practice. [PDF]
Gotchac J +5 more
europepmc +1 more source
Cerebral Hemodynamic Changes During Cardiac Surgery: A Feasibility MR Study in Piglets
Congenital heart disease surgery in infants requires cardiopulmonary bypass (CPB), which increases the risk of brain injury. Conventional heart‐lung machines (HLMs) cannot operate inside MRI scanners, limiting real‐time assessment of cerebral changes. We developed an MR‐conditional HLM and tested it in piglets during CPB.
Dominik T. Schulte +13 more
wiley +1 more source
Traditional and non-traditional behavioral tests demonstrate the attenuation of cognitive deficits by therapeutic hypothermia in a rat model of neonatal hypoxic-ischemic encephalopathy. [PDF]
Saadat A +8 more
europepmc +1 more source

