Results 51 to 60 of about 1,560,342 (283)
Frontiers in Pediatrics, 2023 IntroductionTherapeutic hypothermia is the only proven neuroprotective treatment for hypoxic-ischemic encephalopathy. However, studies have questioned whether therapeutic hypothermia may benefit newborns subjected to infection or inflammation before a ...
Mads Andersen +17 more
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Advanced Science, EarlyView.Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong +24 more
wiley +1 more source
Health Technology Assessment, 2021 Background: Therapeutic hypothermia is standard of care for babies with moderate to severe hypoxic–ischaemic encephalopathy. There is limited evidence to inform provision of nutrition during hypothermia.
Chris Gale +8 more
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Updates on Selective Brain Hypothermia: Studies From Bench Work to Clinical Trials
Frontiers in Neurology, 2022 Thrombectomy or thrombolysis are the current standards of care for acute ischemic stroke (AIS), however, due to time constraints regarding operations and a multitude of contraindications, AIS remains one of the leading causes of death and chronic ...
Xiaoyu Wang +8 more
doaj +1 more source
Therapeutic Hypothermia for Neonatal Encephalopathy [PDF]
Current Treatment Options in Neurology, 2012 Neonatal Hypoxic-ischemic encephalopathy in full term infants has been associated with a high risk for morbidity and mortality. The patho-physiology of brain injury following hypoxia-ischemia, noted in preclinical models, is a cascade of events resulting from excitotoxic and oxidative injury culminating in cell death.
openaire +3 more sources
UFL1‐Mediated UFMylation of ENO1 Restrains Aerobic Glycolysis and Colorectal Cancer Progression
Advanced Science, EarlyView.UFMylation restrains aerobic glycolysis and colorectal cancer progression by modifying the glycolytic enzyme ENO1. Pharmacological enhancement of the UFL1–ENO1 interaction by the FDA‐approved antibiotic torezolid promotes ENO1 UFMylation, suppresses tumor metabolism, and sensitizes colorectal cancer to chemotherapy, revealing an actionable metabolic ...
Xiuqing Ma +14 more
wiley +1 more source
Timing of therapeutic hypothermia for inborn and outborn infants with neonatal encephalopathy [PDF]
, 2017 Therapeutic hypothermia is now the standard of care for infants with moderate to severe hypoxic ischaemic encephalopathy. Sixty-three infants received therapeutic hypothermia at Cork University Maternity Hospital (CUMH) from 2010-2014. Median gestational
Livingstone, Vicki +4 more
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Combination treatment of hypothermia and mesenchymal stromal cells amplifies neuroprotection in primary rat neurons exposed to hypoxic-ischemic-like injury in vitro: role of the opioid system. [PDF]
PLoS ONE, 2012 This study was designed to reveal the therapeutic regimen and mechanism of action underlying hypothermia treatment in combination with stem cell transplantation for ameliorating neonatal hypoxic-ischemic-like injury.
Yuji Kaneko +4 more
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Cardioprotective Effect of Therapeutic Hypothermia for Postresuscitation Myocardial Dysfunction
, 2011 Mild-to-moderate therapeutic hypothermia after resuscitation from cardiac arrest is neuroprotective, but its effect on postresuscitation myocardial dysfunction is not clear.
HSU, CHIUNG-YUAN;HUANG, CHIEN-HUA;CHANG, WEI-TIEN;CHEN, HUEI-WEN;CHENG, HSIAO-JU;TSAI, MIN-SHAN;WANG, TZUNG-DAU;YEN, ZUI-SHEN;LEE, CHIEN-CHANG;CHEN, SHYR-CHYR;CHEN, WEN-JONE +1 more
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Advanced Science, EarlyView.Hypoxia‐adaptive bioelectronics based on poly(3,4‐ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS)/polydopamine (PDA)/enzyme biocomposites couple O2‐centric biosensing with embedded O2 therapy to address oxygen‐deficient chronic wounds. Local O2 provision restores enzyme‐based metabolite sensing, while catalase‐mediated oxygen generation and
Songrui Liu +16 more
wiley +1 more source